Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4909903..4910519 Replicon chromosome
Accession NZ_OW969904
Organism Citrobacter freundii isolate 0

Toxin (Protein)


Gene name vapC Uniprot ID A0A0J1MQ96
Locus tag LQ142_RS24010 Protein ID WP_003028682.1
Coordinates 4909903..4910277 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6B5NTK4
Locus tag LQ142_RS24015 Protein ID WP_043018956.1
Coordinates 4910277..4910519 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ142_RS23995 (4907406) 4907406..4908308 + 903 WP_106107909.1 formate dehydrogenase O subunit beta -
LQ142_RS24000 (4908305) 4908305..4908940 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
LQ142_RS24005 (4908937) 4908937..4909866 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
LQ142_RS24010 (4909903) 4909903..4910277 - 375 WP_003028682.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ142_RS24015 (4910277) 4910277..4910519 - 243 WP_043018956.1 CopG family transcriptional regulator Antitoxin
LQ142_RS24020 (4910725) 4910725..4911633 + 909 WP_048234226.1 alpha/beta hydrolase -
LQ142_RS24025 (4911784) 4911784..4912725 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
LQ142_RS24030 (4912770) 4912770..4913207 - 438 WP_003840439.1 D-aminoacyl-tRNA deacylase -
LQ142_RS24035 (4913204) 4913204..4914076 - 873 WP_003028669.1 virulence factor BrkB family protein -
LQ142_RS24040 (4914070) 4914070..4914669 - 600 WP_016151258.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13674.89 Da        Isoelectric Point: 9.5622

>T296208 WP_003028682.1 NZ_OW969904:c4910277-4909903 [Citrobacter freundii]
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9451.75 Da        Isoelectric Point: 4.3437

>AT296208 WP_043018956.1 NZ_OW969904:c4910519-4910277 [Citrobacter freundii]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MQ96

Antitoxin

Source ID Structure
AlphaFold DB A0A6B5NTK4

References