Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4480753..4481269 Replicon chromosome
Accession NZ_OW969904
Organism Citrobacter freundii isolate 0

Toxin (Protein)


Gene name relE Uniprot ID A0A0D7LMW6
Locus tag LQ142_RS22005 Protein ID WP_003839578.1
Coordinates 4480753..4481037 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag LQ142_RS22010 Protein ID WP_003839576.1
Coordinates 4481027..4481269 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ142_RS21990 (4477078) 4477078..4477662 + 585 WP_230128069.1 fructose PTS transporter subunit IIA -
LQ142_RS21995 (4478040) 4478040..4480178 + 2139 WP_003025782.1 anaerobic ribonucleoside-triphosphate reductase -
LQ142_RS22000 (4480285) 4480285..4480749 + 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LQ142_RS22005 (4480753) 4480753..4481037 - 285 WP_003839578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ142_RS22010 (4481027) 4481027..4481269 - 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LQ142_RS22015 (4481347) 4481347..4483260 - 1914 WP_106107776.1 BglG family transcription antiterminator -
LQ142_RS22020 (4483282) 4483282..4484022 - 741 WP_048216922.1 KDGP aldolase family protein -
LQ142_RS22025 (4484019) 4484019..4485137 - 1119 WP_048234082.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LQ142_RS22030 (4485121) 4485121..4486254 - 1134 WP_230128072.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.68 Da        Isoelectric Point: 10.0482

>T296206 WP_003839578.1 NZ_OW969904:c4481037-4480753 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT296206 WP_003839576.1 NZ_OW969904:c4481269-4481027 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LMW6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References