Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3805098..3805718 Replicon chromosome
Accession NZ_OW969904
Organism Citrobacter freundii isolate 0

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LQ142_RS18865 Protein ID WP_002892050.1
Coordinates 3805500..3805718 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag LQ142_RS18860 Protein ID WP_003021733.1
Coordinates 3805098..3805472 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ142_RS18850 (3800244) 3800244..3801437 + 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ142_RS18855 (3801460) 3801460..3804609 + 3150 WP_003021736.1 efflux RND transporter permease AcrB -
LQ142_RS18860 (3805098) 3805098..3805472 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
LQ142_RS18865 (3805500) 3805500..3805718 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LQ142_RS18870 (3806025) 3806025..3806576 + 552 WP_230127886.1 maltose O-acetyltransferase -
LQ142_RS18875 (3806693) 3806693..3807163 + 471 WP_119173998.1 YlaC family protein -
LQ142_RS18880 (3807242) 3807242..3807382 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
LQ142_RS18885 (3807384) 3807384..3807644 - 261 WP_003021719.1 type B 50S ribosomal protein L31 -
LQ142_RS18890 (3807833) 3807833..3809386 + 1554 WP_003835927.1 EAL domain-containing protein -
LQ142_RS18895 (3809438) 3809438..3809791 - 354 WP_003831033.1 DUF1428 family protein -
LQ142_RS18900 (3809856) 3809856..3810485 - 630 WP_003021707.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T296204 WP_002892050.1 NZ_OW969904:3805500-3805718 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT296204 WP_003021733.1 NZ_OW969904:3805098-3805472 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References