Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 892355..893009 Replicon chromosome
Accession NZ_OW969904
Organism Citrobacter freundii isolate 0

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag LQ142_RS04335 Protein ID WP_003026936.1
Coordinates 892602..893009 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag LQ142_RS04330 Protein ID WP_003026938.1
Coordinates 892355..892621 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ142_RS04305 (887556) 887556..888989 - 1434 WP_202581009.1 6-phospho-beta-glucosidase BglA -
LQ142_RS04310 (889110) 889110..889838 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
LQ142_RS04315 (889891) 889891..890202 + 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
LQ142_RS04320 (890365) 890365..891024 + 660 WP_003838267.1 hemolysin III family protein -
LQ142_RS04325 (891118) 891118..892098 - 981 WP_230126917.1 tRNA-modifying protein YgfZ -
LQ142_RS04330 (892355) 892355..892621 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
LQ142_RS04335 (892602) 892602..893009 + 408 WP_003026936.1 protein YgfX Toxin
LQ142_RS04340 (893054) 893054..893575 - 522 WP_003026933.1 flavodoxin FldB -
LQ142_RS04345 (893689) 893689..894585 + 897 WP_061549190.1 site-specific tyrosine recombinase XerD -
LQ142_RS04350 (894609) 894609..895322 + 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ142_RS04355 (895328) 895328..897061 + 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T296198 WP_003026936.1 NZ_OW969904:892602-893009 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT296198 WP_003026938.1 NZ_OW969904:892355-892621 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References