Detailed information of TA system TA296196

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 780608..782306
• Replicon: chromosome
• Accession: NZ_OW969904
• Organism: Citrobacter freundii isolate 0

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: LQ142_RS03765
• Protein ID: WP_230126889.1
• Coordinates: 780608..781537 (-)
• Length: 310 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: LQ142_RS03770
• Protein ID: WP_213354186.1
• Coordinates: 781524..782306 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ142_RS03755 (775763)	775763..778051	+	2289	WP_230121777.1	FdhF/YdeP family oxidoreductase	-
LQ142_RS03760 (778205)	778205..780064	+	1860	WP_003838200.1	bifunctional glutathionylspermidine amidase/synthase	-
LQ142_RS03765 (780608)	780608..781537	-	930	WP_230126889.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LQ142_RS03770 (781524)	781524..782306	-	783	WP_213354186.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
LQ142_RS03775 (782598)	782598..785693	+	3096	WP_230126891.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-268)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 310 a.a.
• Molecular weight: 34954.28 Da
• Isoelectric Point: 6.9542

>T296196 WP_230126889.1 NZ_OW969904:c781537-780608 [Citrobacter freundii]
MDLRDSYARQVRLLMTALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKTYADRDTDLAAINDALMRITESLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPTEMPVCEQVEMEYGFTTMNVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLAGHPRPIAELLAPNWDTARITTLYAQEFSGMTQQETSLESLQSVKTLLPQAL
KSHLTERDRQFLLSYKKNSPDWSLYRYPEIQHLPAIRWKLRNLAVLSDKNSAKYAAAVSKLEGVLAQYF

Nucleotide

• Length: 930 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29258.55 Da
• Isoelectric Point: 8.7222

>AT296196 WP_213354186.1 NZ_OW969904:c782306-781524 [Citrobacter freundii]
MPNYLNWLMQNTLPGQVLLQSWLTRNGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGRQQIWLALPAYVKLPGWFAAFEQSATFVTLYTSGLTVDVTPFTTKLNIGDRQLTGSIPELAAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQALLCASHSVKTNRVMLYLARRNAHPYFRYLDQSGIETGTGKRQIVPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp