Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 246459..247090 Replicon chromosome
Accession NZ_OW969904
Organism Citrobacter freundii isolate 0

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag LQ142_RS01155 Protein ID WP_003837806.1
Coordinates 246459..246734 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LQ142_RS01160 Protein ID WP_205688252.1
Coordinates 246731..247090 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ142_RS01145 (242510) 242510..245257 + 2748 WP_172750167.1 ribosome-associated ATPase/putative transporter RbbA -
LQ142_RS01150 (245257) 245257..246381 + 1125 WP_071687967.1 ABC transporter permease -
LQ142_RS01155 (246459) 246459..246734 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
LQ142_RS01160 (246731) 246731..247090 + 360 WP_205688252.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LQ142_RS01165 (247203) 247203..247604 - 402 WP_032937232.1 nickel-responsive transcriptional regulator NikR -
LQ142_RS01170 (247654) 247654..248232 - 579 WP_230126760.1 4'-phosphopantetheinyl transferase AcpT -
LQ142_RS01175 (248295) 248295..249344 - 1050 WP_003023393.1 AI-2E family transporter -
LQ142_RS01180 (249478) 249478..250695 + 1218 WP_230126762.1 MFS transporter -
LQ142_RS01185 (250699) 250699..251256 - 558 WP_003837816.1 DcrB family lipoprotein -
LQ142_RS01190 (251329) 251329..251994 - 666 WP_003837818.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T296193 WP_003837806.1 NZ_OW969904:246459-246734 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13214.98 Da        Isoelectric Point: 4.5462

>AT296193 WP_205688252.1 NZ_OW969904:246731-247090 [Citrobacter freundii]
MIKPKTPNSMEISGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure

References