296190

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4260836..4261455 Replicon chromosome
Accession NZ_OW969781
Organism Klebsiella oxytoca isolate 328

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag LQ195_RS19970 Protein ID WP_004099646.1
Coordinates 4261237..4261455 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag LQ195_RS19965 Protein ID WP_004099648.1
Coordinates 4260836..4261210 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ195_RS19955 (AN2363V1_3911) 4255992..4257185 + 1194 WP_004111040.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ195_RS19960 (AN2363V1_3912) 4257208..4260354 + 3147 WP_004099650.1 multidrug efflux RND transporter permease subunit AcrB -
LQ195_RS19965 (AN2363V1_3913) 4260836..4261210 + 375 WP_004099648.1 Hha toxicity modulator TomB Antitoxin
LQ195_RS19970 (AN2363V1_3914) 4261237..4261455 + 219 WP_004099646.1 HHA domain-containing protein Toxin
LQ195_RS19975 (AN2363V1_3915) 4261616..4262182 + 567 WP_023320460.1 maltose O-acetyltransferase -
LQ195_RS19980 4262151..4262288 - 138 WP_224226357.1 hypothetical protein -
LQ195_RS19985 (AN2363V1_3916) 4262319..4262789 + 471 WP_004111038.1 YlaC family protein -
LQ195_RS19990 (AN2363V1_3917) 4262764..4264218 - 1455 WP_064371883.1 PLP-dependent aminotransferase family protein -
LQ195_RS19995 (AN2363V1_3918) 4264321..4265019 + 699 WP_004099639.1 GNAT family protein -
LQ195_RS20000 (AN2363V1_3919) 4265016..4265156 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LQ195_RS20005 (AN2363V1_3920) 4265156..4265419 - 264 WP_004099638.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T296190 WP_004099646.1 NZ_OW969781:4261237-4261455 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT296190 WP_004099648.1 NZ_OW969781:4260836-4261210 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLVTQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure

References