Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 873559..874216 Replicon chromosome
Accession NZ_OW969781
Organism Klebsiella oxytoca isolate 328

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag LQ195_RS04215 Protein ID WP_004105559.1
Coordinates 873806..874216 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag LQ195_RS04210 Protein ID WP_004105561.1
Coordinates 873559..873825 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ195_RS04185 (AN2363V1_0816) 868738..870171 - 1434 WP_004105576.1 6-phospho-beta-glucosidase -
LQ195_RS04190 (AN2363V1_0817) 870292..871020 - 729 WP_064352017.1 MurR/RpiR family transcriptional regulator -
LQ195_RS04195 (AN2363V1_0818) 871071..871376 + 306 WP_230133524.1 N(4)-acetylcytidine aminohydrolase -
LQ195_RS04200 (AN2363V1_0819) 871544..872203 + 660 WP_004105569.1 hemolysin III family protein -
LQ195_RS04205 (AN2363V1_0820) 872332..873315 - 984 WP_004115279.1 tRNA-modifying protein YgfZ -
LQ195_RS04210 (AN2363V1_0822) 873559..873825 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
LQ195_RS04215 (AN2363V1_0823) 873806..874216 + 411 WP_004105559.1 protein YgfX Toxin
LQ195_RS04220 (AN2363V1_0824) 874225..874746 - 522 WP_004105557.1 flavodoxin FldB -
LQ195_RS04225 (AN2363V1_0825) 874868..875764 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
LQ195_RS04230 (AN2363V1_0826) 875787..876500 + 714 WP_004105554.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ195_RS04235 (AN2363V1_0827) 876506..878239 + 1734 WP_024274698.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T296185 WP_004105559.1 NZ_OW969781:873806-874216 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT296185 WP_004105561.1 NZ_OW969781:873559-873825 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References