Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 653770..654362 Replicon chromosome
Accession NZ_OW969781
Organism Klebsiella oxytoca isolate 328

Toxin (Protein)


Gene name doc Uniprot ID A0A7H4PHG5
Locus tag LQ195_RS03170 Protein ID WP_004105955.1
Coordinates 653988..654362 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2J4YM08
Locus tag LQ195_RS03165 Protein ID WP_004105957.1
Coordinates 653770..653991 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ195_RS03145 (AN2363V1_0612) 649329..649883 + 555 WP_004105965.1 YgjV family protein -
LQ195_RS03150 (AN2363V1_0613) 649900..651147 - 1248 WP_004105963.1 serine/threonine transporter SstT -
LQ195_RS03155 (AN2363V1_0614) 651402..652370 - 969 WP_004115718.1 TerC family protein -
LQ195_RS03160 (AN2363V1_0615) 652621..653610 - 990 WP_070556310.1 Gfo/Idh/MocA family oxidoreductase -
LQ195_RS03165 (AN2363V1_0616) 653770..653991 + 222 WP_004105957.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LQ195_RS03170 (AN2363V1_0617) 653988..654362 + 375 WP_004105955.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LQ195_RS03175 (AN2363V1_0618) 654342..654845 - 504 WP_070556312.1 M48 family metallopeptidase -
LQ195_RS03180 (AN2363V1_0619) 654924..656567 - 1644 WP_064397180.1 glycoside hydrolase family 43 protein -
LQ195_RS03185 (AN2363V1_0620) 656696..657562 - 867 WP_004105950.1 AraC family transcriptional regulator -
LQ195_RS03190 (AN2363V1_0621) 657670..659013 + 1344 WP_004105949.1 glycoside-pentoside-hexuronide (GPH):cation symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13895.93 Da        Isoelectric Point: 6.0769

>T296184 WP_004105955.1 NZ_OW969781:653988-654362 [Klebsiella oxytoca]
MKWVSASEVIAFHDRILQHLPGVKGMSDPGRAEAIIYRVQNRFHYEGVNDIFELAATYWVAIARGHIFNDGNKRTAFFIT
MTFLARNGYLIADEDTRLEELTVLAATGEATVVVLADALRQLAL

Download         Length: 375 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8185.19 Da        Isoelectric Point: 5.7996

>AT296184 WP_004105957.1 NZ_OW969781:653770-653991 [Klebsiella oxytoca]
MRSYSTSEARQNIAAVMDAAASGEPIEITRRDGTSNVLISKAEYETFMNAKLDAEFDFIMQRHGRTVKALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4PHG5

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4YM08

References