Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 83952..84982 | Replicon | chromosome |
| Accession | NZ_OW969781 | ||
| Organism | Klebsiella oxytoca isolate 328 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | LQ195_RS00420 | Protein ID | WP_017145221.1 |
| Coordinates | 84407..84982 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | - |
| Locus tag | LQ195_RS00415 | Protein ID | WP_004106993.1 |
| Coordinates | 83952..84407 (+) | Length | 152 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LQ195_RS00390 (AN2363V1_0078) | 79702..80655 | + | 954 | WP_135800215.1 | helix-turn-helix domain-containing protein | - |
| LQ195_RS00395 (AN2363V1_0079) | 80652..81701 | - | 1050 | WP_004107002.1 | NAD(P)-dependent alcohol dehydrogenase | - |
| LQ195_RS00400 (AN2363V1_0080) | 81860..82162 | - | 303 | WP_049127699.1 | putative quinol monooxygenase | - |
| LQ195_RS00405 (AN2363V1_0081) | 82164..83171 | - | 1008 | WP_017145218.1 | zinc-binding alcohol dehydrogenase family protein | - |
| LQ195_RS00410 (AN2363V1_0082) | 83284..83751 | - | 468 | WP_064344103.1 | DUF3237 domain-containing protein | - |
| LQ195_RS00415 (AN2363V1_0083) | 83952..84407 | + | 456 | WP_004106993.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LQ195_RS00420 (AN2363V1_0084) | 84407..84982 | + | 576 | WP_017145221.1 | PIN domain-containing protein | Toxin |
| LQ195_RS27000 | 85261..85383 | + | 123 | WP_094298907.1 | hypothetical protein | - |
| LQ195_RS00425 (AN2363V1_0085) | 85863..86972 | - | 1110 | WP_023339338.1 | HNH endonuclease | - |
| LQ195_RS00430 (AN2363V1_0086) | 87346..89679 | - | 2334 | WP_070556460.1 | primase-like DNA-binding domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 83284..94539 | 11255 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21806.46 Da Isoelectric Point: 6.9659
>T296183 WP_017145221.1 NZ_OW969781:84407-84982 [Klebsiella oxytoca]
MRHSPYPVILDACVLYPARLRDLLMHLGIAGLYQPKWSRCIQDEWCRNLIANRPDILPETLQRTVKMMNSALPDANVTGY
KGLISNLHLPDPNDRHVLAAAIRAKAEIIVTLNHKDFPPELLGPYEIETLHPDAFISDLFDLNHALTLEAVRRQRLSLKH
PSMAVDEFLEMLLKQGLPMTVKELAHYQYAI
MRHSPYPVILDACVLYPARLRDLLMHLGIAGLYQPKWSRCIQDEWCRNLIANRPDILPETLQRTVKMMNSALPDANVTGY
KGLISNLHLPDPNDRHVLAAAIRAKAEIIVTLNHKDFPPELLGPYEIETLHPDAFISDLFDLNHALTLEAVRRQRLSLKH
PSMAVDEFLEMLLKQGLPMTVKELAHYQYAI
Download Length: 576 bp
Antitoxin
Download Length: 152 a.a. Molecular weight: 17068.56 Da Isoelectric Point: 6.4953
>AT296183 WP_004106993.1 NZ_OW969781:83952-84407 [Klebsiella oxytoca]
MTTLTHLNLPDRQESELAQRGQRELAAYLSTRLETQRIAIVGEDDKAHTIELPTSALTLLMEILGELASGNAVQIVPVHA
ELTTQEAANILNVSRPHMVKLLEARKLPFHKTGRHRRVLFADLMEYKKRREQESLDAMQSLADQAQDLGMY
MTTLTHLNLPDRQESELAQRGQRELAAYLSTRLETQRIAIVGEDDKAHTIELPTSALTLLMEILGELASGNAVQIVPVHA
ELTTQEAANILNVSRPHMVKLLEARKLPFHKTGRHRRVLFADLMEYKKRREQESLDAMQSLADQAQDLGMY
Download Length: 456 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|