Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 60869..61416 Replicon chromosome
Accession NZ_OW969781
Organism Klebsiella oxytoca isolate 328

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag LQ195_RS00300 Protein ID WP_064344021.1
Coordinates 60869..61177 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag LQ195_RS00305 Protein ID WP_064344020.1
Coordinates 61180..61416 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ195_RS00275 (AN2363V1_0055) 56773..57084 - 312 WP_004107048.1 PTS sugar transporter subunit IIB -
LQ195_RS00280 (AN2363V1_0056) 57379..58320 + 942 WP_064344024.1 LacI family DNA-binding transcriptional regulator -
LQ195_RS00285 (AN2363V1_0057) 58344..58640 - 297 WP_224250553.1 YicS family protein -
LQ195_RS00290 (AN2363V1_0058) 58851..59813 + 963 WP_024274836.1 Rpn family recombination-promoting nuclease/putative transposase -
LQ195_RS00295 (AN2363V1_0059) 59817..60719 - 903 WP_004107039.1 DMT family transporter -
LQ195_RS00300 (AN2363V1_0060) 60869..61177 - 309 WP_064344021.1 CcdB family protein Toxin
LQ195_RS00305 (AN2363V1_0061) 61180..61416 - 237 WP_064344020.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LQ195_RS00310 (AN2363V1_0062) 61522..62955 - 1434 WP_210669531.1 PTS N-acetylmuramic acid transporter subunit IIBC -
LQ195_RS00315 (AN2363V1_0063) 62980..63882 - 903 WP_004107035.1 N-acetylmuramic acid 6-phosphate etherase -
LQ195_RS00320 (AN2363V1_0064) 64044..65210 - 1167 WP_210669532.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11726.51 Da        Isoelectric Point: 6.2188

>T296182 WP_064344021.1 NZ_OW969781:c61177-60869 [Klebsiella oxytoca]
MQYYVYKNTGRIAAYPYLLDVQSDIIGERNTRVVIPLFPLKNYKGPRADRLTPLVTVEGEEYVVMTHELASIPHRVLGEE
VCNLNHQREVVKASMDFLFDGI

Download         Length: 309 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8768.95 Da        Isoelectric Point: 5.7928

>AT296182 WP_064344020.1 NZ_OW969781:c61416-61180 [Klebsiella oxytoca]
MPAAKRNKQNVSVTLDPGLVKQAREVGINLSLTLTNALKSEIHSLEIARWQKENALAIDYLNNLTEENGLLSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References