296181

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4455603..4456219 Replicon chromosome
Accession NZ_OW969711
Organism Citrobacter koseri isolate 0

Toxin (Protein)


Gene name vapC Uniprot ID A0A427P7X6
Locus tag LQV24_RS21130 Protein ID WP_047459878.1
Coordinates 4455603..4455977 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LQV24_RS21135 Protein ID WP_160880417.1
Coordinates 4455977..4456219 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV24_RS21115 (4453106) 4453106..4454008 + 903 WP_012133916.1 formate dehydrogenase O subunit beta -
LQV24_RS21120 (4454005) 4454005..4454640 + 636 WP_049011887.1 formate dehydrogenase cytochrome b556 subunit -
LQV24_RS21125 (4454637) 4454637..4455566 + 930 WP_047459875.1 formate dehydrogenase accessory protein FdhE -
LQV24_RS21130 (4455603) 4455603..4455977 - 375 WP_047459878.1 type II toxin-antitoxin system VapC family toxin Toxin
LQV24_RS21135 (4455977) 4455977..4456219 - 243 WP_160880417.1 CopG family transcriptional regulator Antitoxin
LQV24_RS21140 (4456424) 4456424..4457353 + 930 WP_230012452.1 alpha/beta hydrolase -
LQV24_RS21145 (4457405) 4457405..4457675 + 271 Protein_4135 hypothetical protein -
LQV24_RS21150 (4457697) 4457697..4458638 - 942 WP_024130670.1 fatty acid biosynthesis protein FabY -
LQV24_RS21155 (4458683) 4458683..4459120 - 438 WP_047459887.1 D-aminoacyl-tRNA deacylase -
LQV24_RS21160 (4459117) 4459117..4459989 - 873 WP_012133924.1 virulence factor BrkB family protein -
LQV24_RS21165 (4459983) 4459983..4460582 - 600 WP_104867942.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13799.04 Da        Isoelectric Point: 9.4395

>T296181 WP_047459878.1 NZ_OW969711:c4455977-4455603 [Citrobacter koseri]
MIKGPVLFDTNILIDLFSGRDEAKKALEAYSPQNAISLITWMEVMVGAKKYHQESRTRIALSAFNVIGVSQDIAERSVSL
RQEYGMKLPDAVILATAHIHRFALVTRNTKDFAGIPGVITPYHL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9396.62 Da        Isoelectric Point: 4.1961

>AT296181 WP_160880417.1 NZ_OW969711:c4456219-4455977 [Citrobacter koseri]
MMAGMEMGRILLDLSDEVIKRLDDLKQQRNLPRAELLREAVEQYLERQGQAETTISDALGLWQGCEEDGVEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A427P7X6

Antitoxin

Source ID Structure

References