296178

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3396860..3397480 Replicon chromosome
Accession NZ_OW969711
Organism Citrobacter koseri isolate 0

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LQV24_RS16325 Protein ID WP_002892050.1
Coordinates 3397262..3397480 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A8AJY4
Locus tag LQV24_RS16320 Protein ID WP_012133514.1
Coordinates 3396860..3397234 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV24_RS16310 (3391996) 3391996..3393189 + 1194 WP_049009804.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQV24_RS16315 (3393212) 3393212..3396358 + 3147 WP_012133513.1 efflux RND transporter permease AcrB -
LQV24_RS16320 (3396860) 3396860..3397234 + 375 WP_012133514.1 Hha toxicity modulator TomB Antitoxin
LQV24_RS16325 (3397262) 3397262..3397480 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LQV24_RS16330 (3397664) 3397664..3398215 + 552 WP_049009805.1 maltose O-acetyltransferase -
LQV24_RS16335 (3398329) 3398329..3398799 + 471 WP_024130587.1 YlaC family protein -
LQV24_RS16340 (3398877) 3398877..3399017 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LQV24_RS16345 (3399019) 3399019..3399279 - 261 WP_012133519.1 type B 50S ribosomal protein L31 -
LQV24_RS16350 (3399505) 3399505..3401055 + 1551 WP_230011808.1 EAL domain-containing protein -
LQV24_RS16355 (3401095) 3401095..3401448 - 354 WP_012133521.1 DUF1428 family protein -
LQV24_RS16360 (3401528) 3401528..3402142 - 615 WP_012133522.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T296178 WP_002892050.1 NZ_OW969711:3397262-3397480 [Citrobacter koseri]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14437.27 Da        Isoelectric Point: 5.1444

>AT296178 WP_012133514.1 NZ_OW969711:3396860-3397234 [Citrobacter koseri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A8AJY4

References