Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2942099..2942838 Replicon chromosome
Accession NZ_OW969711
Organism Citrobacter koseri isolate 0

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag LQV24_RS14095 Protein ID WP_230011416.1
Coordinates 2942099..2942584 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag LQV24_RS14100 Protein ID WP_230011418.1
Coordinates 2942572..2942838 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV24_RS14070 (2937371) 2937371..2938948 + 1578 WP_114848472.1 peptidoglycan-binding domain-containing protein -
LQV24_RS14075 (2938948) 2938948..2939448 + 501 WP_114848473.1 hypothetical protein -
LQV24_RS14080 (2939534) 2939534..2940157 - 624 WP_012133085.1 helix-turn-helix domain-containing protein -
LQV24_RS14085 (2940451) 2940451..2941281 - 831 WP_047457875.1 N-acetylmuramoyl-L-alanine amidase -
LQV24_RS14090 (2941278) 2941278..2941601 - 324 WP_012133087.1 heavy metal-binding domain-containing protein -
LQV24_RS14095 (2942099) 2942099..2942584 - 486 WP_230011416.1 GNAT family N-acetyltransferase Toxin
LQV24_RS14100 (2942572) 2942572..2942838 - 267 WP_230011418.1 DUF1778 domain-containing protein Antitoxin
LQV24_RS14105 (2943007) 2943007..2944167 + 1161 Protein_2767 IS30 family transposase -
LQV24_RS14110 (2944488) 2944488..2944934 - 447 WP_230011420.1 helix-turn-helix domain-containing protein -
LQV24_RS14115 (2945082) 2945082..2945858 + 777 WP_230011422.1 SDR family oxidoreductase -
LQV24_RS14120 (2945869) 2945869..2946288 + 420 WP_230011437.1 tautomerase family protein -
LQV24_RS14125 (2946540) 2946540..2947010 - 471 WP_230011440.1 tail fiber assembly protein -
LQV24_RS14130 (2947026) 2947026..2947628 - 603 WP_230011443.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2940705..2996074 55369
- flank IS/Tn - - 2943505..2943978 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17831.59 Da        Isoelectric Point: 10.2935

>T296177 WP_230011416.1 NZ_OW969711:c2942584-2942099 [Citrobacter koseri]
VGRVTAPEPLSAFHQVAEFVSGEAVLDNWLKQKGLKNQTLGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHRKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10148.58 Da        Isoelectric Point: 4.3837

>AT296177 WP_230011418.1 NZ_OW969711:c2942838-2942572 [Citrobacter koseri]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYTEFIDMLDAPVADDPVIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References