Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 833129..833783 Replicon chromosome
Accession NZ_OW969711
Organism Citrobacter koseri isolate 0

Toxin (Protein)


Gene name cptA Uniprot ID A0A078LNB4
Locus tag LQV24_RS03970 Protein ID WP_024130921.1
Coordinates 833376..833783 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A078LG12
Locus tag LQV24_RS03965 Protein ID WP_024130922.1
Coordinates 833129..833395 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV24_RS03940 (828278) 828278..829711 - 1434 WP_012135007.1 6-phospho-beta-glucosidase BglA -
LQV24_RS03945 (829832) 829832..830560 - 729 WP_012135006.1 MurR/RpiR family transcriptional regulator -
LQV24_RS03950 (830613) 830613..830924 + 312 WP_047461422.1 N(4)-acetylcytidine aminohydrolase -
LQV24_RS03955 (831086) 831086..831745 + 660 WP_230010016.1 hemolysin III family protein -
LQV24_RS03960 (831892) 831892..832872 - 981 WP_230010019.1 tRNA-modifying protein YgfZ -
LQV24_RS03965 (833129) 833129..833395 + 267 WP_024130922.1 FAD assembly factor SdhE Antitoxin
LQV24_RS03970 (833376) 833376..833783 + 408 WP_024130921.1 protein YgfX Toxin
LQV24_RS03975 (833873) 833873..834397 - 525 WP_012134999.1 flavodoxin FldB -
LQV24_RS03980 (834501) 834501..835397 + 897 WP_012134998.1 site-specific tyrosine recombinase XerD -
LQV24_RS03985 (835421) 835421..836134 + 714 WP_012134997.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQV24_RS03990 (836140) 836140..837873 + 1734 WP_230010021.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15888.77 Da        Isoelectric Point: 11.2845

>T296171 WP_024130921.1 NZ_OW969711:833376-833783 [Citrobacter koseri]
VVLWQSDLRVSWRAQWLSLLIHGLVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRINTRQGEIKLLMDGRLRWQGQ
DWTIQGPPWMLKTGMMLRLRADSGKRQHLWLAADSMDDAEWRDLRRLMLQQATQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10476.00 Da        Isoelectric Point: 4.8836

>AT296171 WP_024130922.1 NZ_OW969711:833129-833395 [Citrobacter koseri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDEEKCIFVRLLECDDPDLFNWLMNHGKPGDAELEQMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A078LNB4

Antitoxin

Source ID Structure
AlphaFold DB A0A078LG12

References