296170

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1940..2499 Replicon plasmid P1
Accession NZ_OW969692
Organism Citrobacter koseri isolate 0

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag LQV22_RS22135 Protein ID WP_000421257.1
Coordinates 2224..2499 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag LQV22_RS22130 Protein ID WP_001178089.1
Coordinates 1940..2224 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV22_RS22125 (AN2351V1_4290) 1..1032 + 1032 WP_000907880.1 plasmid replication initiator RepA -
LQV22_RS22130 (AN2351V1_4291) 1940..2224 + 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
LQV22_RS22135 (AN2351V1_4292) 2224..2499 + 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQV22_RS22140 (AN2351V1_4293) 2605..2886 + 282 WP_001105066.1 hypothetical protein -
LQV22_RS22145 3077..3343 - 267 WP_000627831.1 hypothetical protein -
LQV22_RS22150 (AN2351V1_4294) 3581..4183 - 603 WP_000517694.1 ProQ/FINO family protein -
LQV22_RS22155 (AN2351V1_4295) 4537..5883 + 1347 WP_001132025.1 protein YagA -
LQV22_RS22160 6442..6744 - 303 WP_001245884.1 hypothetical protein -
LQV22_RS22165 (AN2351V1_4296) 6741..7367 - 627 WP_000587689.1 ParA family plasmid-partitioning AAA ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid floR / aph(6)-Id / blaTEM-1C / aph(3'')-Ib / sul2 - 1..103689 103689


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T296170 WP_000421257.1 NZ_OW969692:2224-2499 [Citrobacter koseri]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT296170 WP_001178089.1 NZ_OW969692:1940-2224 [Citrobacter koseri]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References