Detailed information of TA system TA029617

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 508334..509007
• Replicon: chromosome
• Accession: NC_021663
• Organism: Corynebacterium terpenotabidum Y-11

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: S4XEP7
• Locus tag: A606_RS02160
• Protein ID: WP_020440445.1
• Coordinates: 508334..508756 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: A606_RS02165
• Protein ID: WP_041631273.1
• Coordinates: 508753..509007 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A606_RS02140	504628..505233	-	606	WP_020440441.1	hypothetical protein	-
A606_RS02145	505382..505975	+	594	WP_020440442.1	transcription factor	-
A606_RS02150	505979..506878	-	900	WP_020440443.1	fumarylacetoacetate hydrolase family protein	-
A606_RS02155	506905..508326	+	1422	WP_020440444.1	cysteine--tRNA ligase	-
A606_RS02160	508334..508756	-	423	WP_020440445.1	type II toxin-antitoxin system VapC family toxin	Toxin
A606_RS02165	508753..509007	-	255	WP_041631273.1	plasmid stabilization protein	Antitoxin
A606_RS02170	509119..510531	-	1413	WP_020440447.1	MFS transporter	-
A606_RS02175	510614..511567	+	954	WP_020440448.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
A606_RS02180	511572..512450	-	879	WP_084680626.1	metal ABC transporter permease	-
A606_RS02185	512462..513166	-	705	WP_020440450.1	metal ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15055.19 Da
• Isoelectric Point: 7.0113

>T29617 WP_020440445.1 NC_021663:c508756-508334 [Corynebacterium terpenotabidum Y-11]
VIVLDTNIVSEAMRPRPNPSVITWLNRQAADTLYLSSVSLAELLFGIGALPEGKRRDRLNTALDQLLVLFSGRIIPFDAD
AARHYAQMAVAARNVGRPLAMADGYIAATAAARGFTVATRNTVDFETTGVSLINPGTDQQ

Nucleotide

• Length: 423 bp

>T29617 NC_021663:c508756-508334 [Corynebacterium terpenotabidum Y-11]
GTGATCGTCCTCGACACCAACATCGTCTCCGAGGCGATGCGGCCACGACCTAACCCCTCAGTCATCACCTGGCTGAACCG
CCAGGCCGCAGACACGCTCTACCTGTCCAGCGTCTCCCTGGCGGAGCTACTCTTCGGCATCGGAGCACTTCCGGAAGGGA
AGCGCAGAGACCGCCTCAACACGGCACTCGATCAGCTTCTGGTGCTCTTCTCCGGTCGTATTATCCCCTTCGACGCCGAT
GCCGCCCGCCACTACGCGCAGATGGCCGTCGCAGCACGGAACGTCGGCCGGCCGTTGGCCATGGCGGACGGATACATCGC
CGCCACCGCTGCAGCACGGGGTTTCACGGTCGCGACCAGGAACACCGTGGACTTCGAGACCACCGGAGTCTCCCTCATCA
ATCCCGGGACCGATCAGCAGTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9150.23 Da
• Isoelectric Point: 4.8007

>AT29617 WP_041631273.1 NC_021663:c509007-508753 [Corynebacterium terpenotabidum Y-11]
MANLTVRNVPDDIHRALRAQAKAHGRSAEAEVRQILGDALIPSNRLHIGDALAALGRELDLTDEDVDVLESTRNRSSAEP
MDLP

Nucleotide

• Length: 255 bp

>AT29617 NC_021663:c509007-508753 [Corynebacterium terpenotabidum Y-11]
ATGGCCAACCTGACCGTCCGCAATGTTCCCGACGATATCCACCGCGCCCTTCGCGCGCAGGCCAAGGCCCACGGCCGCAG
CGCAGAAGCAGAGGTGCGTCAGATCCTGGGCGATGCCCTCATCCCTTCGAACAGGCTCCATATCGGTGACGCCCTGGCGG
CACTCGGACGTGAACTCGACCTCACCGATGAGGACGTCGATGTTCTGGAATCCACCCGCAACCGGTCTAGCGCTGAGCCG
ATGGACCTTCCGTGA

Structures

Toxin

• AlphaFold DB: S4XEP7