296169

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4482978..4483594 Replicon chromosome
Accession NZ_OW969691
Organism Citrobacter koseri isolate 0

Toxin (Protein)


Gene name vapC Uniprot ID A0A427P7X6
Locus tag LQV22_RS21265 Protein ID WP_047459878.1
Coordinates 4482978..4483352 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LQV22_RS21270 Protein ID WP_160880417.1
Coordinates 4483352..4483594 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV22_RS21250 (4480481) 4480481..4481383 + 903 WP_071259455.1 formate dehydrogenase O subunit beta -
LQV22_RS21255 (4481380) 4481380..4482015 + 636 WP_012133917.1 formate dehydrogenase cytochrome b556 subunit -
LQV22_RS21260 (4482012) 4482012..4482941 + 930 WP_047459875.1 formate dehydrogenase accessory protein FdhE -
LQV22_RS21265 (4482978) 4482978..4483352 - 375 WP_047459878.1 type II toxin-antitoxin system VapC family toxin Toxin
LQV22_RS21270 (4483352) 4483352..4483594 - 243 WP_160880417.1 CopG family transcriptional regulator Antitoxin
LQV22_RS21275 (4483831) 4483831..4484772 - 942 WP_024130670.1 fatty acid biosynthesis protein FabY -
LQV22_RS21280 (4484817) 4484817..4485254 - 438 WP_047459887.1 D-aminoacyl-tRNA deacylase -
LQV22_RS21285 (4485251) 4485251..4486123 - 873 WP_230032323.1 virulence factor BrkB family protein -
LQV22_RS21290 (4486117) 4486117..4486716 - 600 WP_047459890.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13799.04 Da        Isoelectric Point: 9.4395

>T296169 WP_047459878.1 NZ_OW969691:c4483352-4482978 [Citrobacter koseri]
MIKGPVLFDTNILIDLFSGRDEAKKALEAYSPQNAISLITWMEVMVGAKKYHQESRTRIALSAFNVIGVSQDIAERSVSL
RQEYGMKLPDAVILATAHIHRFALVTRNTKDFAGIPGVITPYHL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9396.62 Da        Isoelectric Point: 4.1961

>AT296169 WP_160880417.1 NZ_OW969691:c4483594-4483352 [Citrobacter koseri]
MMAGMEMGRILLDLSDEVIKRLDDLKQQRNLPRAELLREAVEQYLERQGQAETTISDALGLWQGCEEDGVEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A427P7X6

Antitoxin

Source ID Structure

References