Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3384191..3384811 Replicon chromosome
Accession NZ_OW969691
Organism Citrobacter koseri isolate 0

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LQV22_RS16115 Protein ID WP_002892050.1
Coordinates 3384593..3384811 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag LQV22_RS16110 Protein ID WP_214143481.1
Coordinates 3384191..3384565 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV22_RS16100 (3379327) 3379327..3380520 + 1194 WP_047458420.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQV22_RS16105 (3380543) 3380543..3383689 + 3147 WP_012133513.1 efflux RND transporter permease AcrB -
LQV22_RS16110 (3384191) 3384191..3384565 + 375 WP_214143481.1 Hha toxicity modulator TomB Antitoxin
LQV22_RS16115 (3384593) 3384593..3384811 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LQV22_RS16120 (3384995) 3384995..3385546 + 552 WP_049009805.1 maltose O-acetyltransferase -
LQV22_RS16125 (3385660) 3385660..3386130 + 471 WP_024130587.1 YlaC family protein -
LQV22_RS16130 (3386208) 3386208..3386348 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LQV22_RS16135 (3386350) 3386350..3386610 - 261 WP_012133519.1 type B 50S ribosomal protein L31 -
LQV22_RS16140 (3386836) 3386836..3388386 + 1551 WP_114847716.1 EAL domain-containing protein -
LQV22_RS16145 (3388426) 3388426..3388779 - 354 WP_012133521.1 DUF1428 family protein -
LQV22_RS16150 (3388859) 3388859..3389473 - 615 WP_101743908.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T296168 WP_002892050.1 NZ_OW969691:3384593-3384811 [Citrobacter koseri]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14467.30 Da        Isoelectric Point: 5.1444

>AT296168 WP_214143481.1 NZ_OW969691:3384191-3384565 [Citrobacter koseri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSTINLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure

References