296166

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2287045..2287684 Replicon chromosome
Accession NZ_OW969691
Organism Citrobacter koseri isolate 0

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LQV22_RS10880 Protein ID WP_072271874.1
Coordinates 2287045..2287221 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LQV22_RS10885 Protein ID WP_125337124.1
Coordinates 2287268..2287684 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV22_RS10860 (2282138) 2282138..2283013 + 876 WP_012132344.1 AraC family transcriptional regulator -
LQV22_RS10865 (2282990) 2282990..2284156 - 1167 WP_112002075.1 benzoate/H(+) symporter BenE family transporter -
LQV22_RS10870 (2284249) 2284249..2284785 + 537 WP_058669186.1 XRE family transcriptional regulator -
LQV22_RS10875 (2284864) 2284864..2286825 + 1962 WP_230032101.1 U32 family peptidase -
LQV22_RS10880 (2287045) 2287045..2287221 + 177 WP_072271874.1 type II toxin-antitoxin system HicA family toxin Toxin
LQV22_RS10885 (2287268) 2287268..2287684 + 417 WP_125337124.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LQV22_RS10890 (2287736) 2287736..2289145 + 1410 WP_110494249.1 PLP-dependent aminotransferase family protein -
LQV22_RS10895 (2289465) 2289465..2290889 + 1425 WP_115181620.1 aminobutyraldehyde dehydrogenase -
LQV22_RS10900 (2290988) 2290988..2291083 - 96 WP_071818853.1 stress response membrane protein YncL -
LQV22_RS10905 (2291275) 2291275..2291448 + 174 WP_047464087.1 GhoT/OrtT family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6794.76 Da        Isoelectric Point: 10.8122

>T296166 WP_072271874.1 NZ_OW969691:2287045-2287221 [Citrobacter koseri]
VKQSEFRRWLESQGVDVTNGTNHLKLRYHDKRSVMPRHPGDEIKDTLRKAILKQPGLN

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15370.62 Da        Isoelectric Point: 4.4377

>AT296166 WP_125337124.1 NZ_OW969691:2287268-2287684 [Citrobacter koseri]
MRYPVNLIPAEEGGYVVSFPDIPEALTQGDTRHESLEAAQGALVTAFEFYFEDNQPIPLPSMVDEADDYVEIPLSIASKV
LLLNAFLESKITQQELARRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSLTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References