Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 839300..839954 Replicon chromosome
Accession NZ_OW969691
Organism Citrobacter koseri isolate 0

Toxin (Protein)


Gene name cptA Uniprot ID A0A078LNB4
Locus tag LQV22_RS04070 Protein ID WP_024130921.1
Coordinates 839547..839954 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A078LG12
Locus tag LQV22_RS04065 Protein ID WP_024130922.1
Coordinates 839300..839566 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV22_RS04040 (834441) 834441..835874 - 1434 WP_012135007.1 6-phospho-beta-glucosidase BglA -
LQV22_RS04045 (835995) 835995..836723 - 729 WP_012135006.1 MurR/RpiR family transcriptional regulator -
LQV22_RS04050 (836776) 836776..837087 + 312 WP_012135005.1 N(4)-acetylcytidine aminohydrolase -
LQV22_RS04055 (837249) 837249..837908 + 660 WP_012135004.1 hemolysin III family protein -
LQV22_RS04060 (838063) 838063..839043 - 981 WP_024130923.1 tRNA-modifying protein YgfZ -
LQV22_RS04065 (839300) 839300..839566 + 267 WP_024130922.1 FAD assembly factor SdhE Antitoxin
LQV22_RS04070 (839547) 839547..839954 + 408 WP_024130921.1 protein YgfX Toxin
LQV22_RS04075 (840052) 840052..840576 - 525 WP_012134999.1 flavodoxin FldB -
LQV22_RS04080 (840680) 840680..841576 + 897 WP_012134998.1 site-specific tyrosine recombinase XerD -
LQV22_RS04085 (841600) 841600..842313 + 714 WP_012134997.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQV22_RS04090 (842319) 842319..844052 + 1734 WP_012134996.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15888.77 Da        Isoelectric Point: 11.2845

>T296161 WP_024130921.1 NZ_OW969691:839547-839954 [Citrobacter koseri]
VVLWQSDLRVSWRAQWLSLLIHGLVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRINTRQGEIKLLMDGRLRWQGQ
DWTIQGPPWMLKTGMMLRLRADSGKRQHLWLAADSMDDAEWRDLRRLMLQQATQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10476.00 Da        Isoelectric Point: 4.8836

>AT296161 WP_024130922.1 NZ_OW969691:839300-839566 [Citrobacter koseri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDEEKCIFVRLLECDDPDLFNWLMNHGKPGDAELEQMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A078LNB4

Antitoxin

Source ID Structure
AlphaFold DB A0A078LG12

References