296158

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 139716..140452 Replicon plasmid P1
Accession NZ_OW969660
Organism Klebsiella oxytoca isolate 36

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag LQ206_RS27990 Protein ID WP_003026803.1
Coordinates 139970..140452 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag LQ206_RS27985 Protein ID WP_003026799.1
Coordinates 139716..139982 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ206_RS27950 (AI2918V1_5445) 135560..135922 - 363 WP_004206665.1 arsenite efflux transporter metallochaperone ArsD -
LQ206_RS27955 (AI2918V1_5446) 135974..136324 - 351 WP_004206664.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
LQ206_RS27960 (AI2918V1_5447) 136682..136930 + 249 WP_004193994.1 hypothetical protein -
LQ206_RS27965 (AI2918V1_5448) 136927..138138 + 1212 WP_032415728.1 hypothetical protein -
LQ206_RS27970 (AI2918V1_5449) 138272..138763 + 492 WP_004206662.1 hypothetical protein -
LQ206_RS27975 (AI2918V1_5450) 138824..139027 + 204 WP_004206661.1 HHA domain-containing protein -
LQ206_RS27980 (AI2918V1_5451) 139041..139271 + 231 WP_004206660.1 hypothetical protein -
LQ206_RS27985 (AI2918V1_5452) 139716..139982 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
LQ206_RS27990 (AI2918V1_5453) 139970..140452 + 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
LQ206_RS27995 (AI2918V1_5454) 140653..142056 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
LQ206_RS28000 (AI2918V1_5455) 142085..142717 - 633 WP_001567369.1 hypothetical protein -
LQ206_RS28005 (AI2918V1_5456) 142936..144339 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
LQ206_RS28010 (AI2918V1_5457) 144368..145000 - 633 WP_001567369.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaTEM-1B mrkA / mrkB / mrkC / mrkF / mrkJ 1..165787 165787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T296158 WP_003026803.1 NZ_OW969660:139970-140452 [Klebsiella oxytoca]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT296158 WP_003026799.1 NZ_OW969660:139716-139982 [Klebsiella oxytoca]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References