Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 5337808..5338583 Replicon chromosome
Accession NZ_OW969659
Organism Klebsiella oxytoca isolate 36

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag LQ206_RS24950 Protein ID WP_064350014.1
Coordinates 5337808..5338293 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag LQ206_RS24955 Protein ID WP_016809050.1
Coordinates 5338290..5338583 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ206_RS24930 5333306..5333602 + 297 Protein_4902 site-specific integrase -
LQ206_RS24935 (AI2918V1_4886) 5333840..5334823 - 984 WP_016809046.1 hypothetical protein -
LQ206_RS24940 (AI2918V1_4887) 5335338..5336369 + 1032 Protein_4904 IS630 family transposase -
LQ206_RS24945 5336724..5336974 + 251 Protein_4905 hypothetical protein -
LQ206_RS24950 (AI2918V1_4888) 5337808..5338293 - 486 WP_064350014.1 GNAT family N-acetyltransferase Toxin
LQ206_RS24955 (AI2918V1_4889) 5338290..5338583 - 294 WP_016809050.1 DUF1778 domain-containing protein Antitoxin
LQ206_RS24960 (AI2918V1_4890) 5338864..5339451 - 588 WP_016809051.1 NAD(P)H-dependent oxidoreductase -
LQ206_RS24965 (AI2918V1_4891) 5339567..5340187 + 621 WP_016809052.1 TetR/AcrR family transcriptional regulator -
LQ206_RS24970 (AI2918V1_4892) 5340256..5341038 - 783 WP_004109379.1 DsbA family protein -
LQ206_RS24975 (AI2918V1_4893) 5341261..5341944 + 684 WP_004109381.1 TerC family protein -
LQ206_RS24980 (AI2918V1_4894) 5342094..5343011 + 918 WP_004109383.1 curved DNA-binding protein -
LQ206_RS24985 (AI2918V1_4895) 5343011..5343316 + 306 WP_004109388.1 chaperone modulator CbpM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 5343554..5344576 1022


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17541.43 Da        Isoelectric Point: 7.8024

>T296156 WP_064350014.1 NZ_OW969659:c5338293-5337808 [Klebsiella oxytoca]
MISAPEPLQAGHILTPFYCGVDSMDNWLKQRAMKNQLSGASRTFVCCDDAKVMAYYSLASSAVATNTAPGRFRRNMPDPI
PVVVLGRLAVDRTLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPIDPMMLMVTLGDLVH
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10990.66 Da        Isoelectric Point: 9.8590

>AT296156 WP_016809050.1 NZ_OW969659:c5338583-5338290 [Klebsiella oxytoca]
MPAANSMTMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPVPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References