Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4323755..4324374 Replicon chromosome
Accession NZ_OW969659
Organism Klebsiella oxytoca isolate 36

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag LQ206_RS20265 Protein ID WP_004099646.1
Coordinates 4324156..4324374 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag LQ206_RS20260 Protein ID WP_004099648.1
Coordinates 4323755..4324129 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ206_RS20250 (AI2918V1_3979) 4318911..4320104 + 1194 WP_004111040.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ206_RS20255 (AI2918V1_3980) 4320127..4323273 + 3147 WP_004099650.1 multidrug efflux RND transporter permease subunit AcrB -
LQ206_RS20260 (AI2918V1_3981) 4323755..4324129 + 375 WP_004099648.1 Hha toxicity modulator TomB Antitoxin
LQ206_RS20265 (AI2918V1_3982) 4324156..4324374 + 219 WP_004099646.1 HHA domain-containing protein Toxin
LQ206_RS20270 (AI2918V1_3983) 4324535..4325101 + 567 WP_230133288.1 maltose O-acetyltransferase -
LQ206_RS20275 4325070..4325207 - 138 WP_224226720.1 hypothetical protein -
LQ206_RS20280 (AI2918V1_3984) 4325238..4325708 + 471 WP_004111038.1 YlaC family protein -
LQ206_RS20285 (AI2918V1_3985) 4325683..4327137 - 1455 WP_016808702.1 PLP-dependent aminotransferase family protein -
LQ206_RS20290 (AI2918V1_3986) 4327240..4327938 + 699 WP_004099639.1 GNAT family protein -
LQ206_RS20295 (AI2918V1_3987) 4327935..4328075 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LQ206_RS20300 (AI2918V1_3988) 4328075..4328338 - 264 WP_004099638.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T296154 WP_004099646.1 NZ_OW969659:4324156-4324374 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT296154 WP_004099648.1 NZ_OW969659:4323755-4324129 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLVTQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure

References