29615

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE(toxin)
Location 5070848..5071419 Replicon chromosome
Accession NC_021659
Organism Serratia plymuthica S13

Toxin (Protein)


Gene name relE Uniprot ID S4YNR1
Locus tag M621_RS48570 Protein ID WP_020439916.1
Coordinates 5071141..5071419 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID S4YTP6
Locus tag M621_RS48565 Protein ID WP_004951261.1
Coordinates 5070848..5071117 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M621_RS48550 5067062..5068279 - 1218 WP_004951256.1 aspartate aminotransferase family protein -
M621_RS48555 5068411..5068986 - 576 WP_006328493.1 aminodeoxychorismate synthase component II -
M621_RS48560 5069092..5070618 - 1527 WP_006328494.1 DUF853 family protein -
M621_RS48565 5070848..5071117 + 270 WP_004951261.1 hypothetical protein Antitoxin
M621_RS48570 5071141..5071419 + 279 WP_020439916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M621_RS48575 5071420..5072145 - 726 WP_004951264.1 two-component system response regulator BtsR -
M621_RS48580 5072145..5073830 - 1686 WP_006328506.1 sensor histidine kinase -
M621_RS48585 5073990..5074559 - 570 WP_006328507.1 peptidylprolyl isomerase A -
M621_RS48590 5074915..5075253 + 339 WP_006328508.1 PTS lactose/cellobiose transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10242.84 Da        Isoelectric Point: 8.5141

>T29615 WP_020439916.1 NC_021659:5071141-5071419 [Serratia plymuthica S13]
VTLKWTEPAIADRIAIYDYLETKNPAAAIEIDSLISATATRLSQNPSSGKPGRVPGTREMVIHHSYFLVYELINGLIIML
AVVHARRQWPAN

Download         Length: 279 bp

>T29615 NC_021659:5071141-5071419 [Serratia plymuthica S13]
GTGACACTCAAGTGGACGGAACCCGCAATTGCCGATCGTATAGCAATTTATGACTACCTGGAAACAAAGAATCCGGCCGC
AGCTATAGAAATTGATAGCTTGATTTCAGCAACTGCGACACGACTCTCACAAAACCCGTCCAGTGGAAAACCAGGTCGAG
TGCCCGGTACACGTGAAATGGTTATTCATCATTCCTATTTTCTGGTTTATGAATTAATCAACGGGTTAATCATTATGCTG
GCCGTAGTTCATGCCCGCCGTCAGTGGCCCGCCAATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10364.70 Da        Isoelectric Point: 7.0169

>AT29615 WP_004951261.1 NC_021659:5070848-5071117 [Serratia plymuthica S13]
MSESTVVIRVDEELKIAFASAAKAADRTASQLLRDFMRDFVSRQTHQKEYEQWLQEKVDLSRKALNEGKITDNEAVEAYF
AERRSKLIR

Download         Length: 270 bp

>AT29615 NC_021659:5070848-5071117 [Serratia plymuthica S13]
ATGTCTGAATCTACCGTGGTTATCCGAGTGGATGAGGAATTAAAAATCGCCTTTGCCAGCGCTGCCAAAGCAGCCGATCG
CACCGCATCTCAGTTGCTGCGCGATTTCATGCGTGATTTTGTCAGCCGGCAAACTCATCAGAAAGAGTATGAGCAGTGGC
TACAGGAAAAAGTGGACTTAAGCCGTAAAGCGCTTAATGAAGGAAAAATCACTGATAATGAAGCCGTTGAGGCCTACTTC
GCTGAACGTAGATCAAAACTGATAAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4YNR1

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1KXK3

References