Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 886018..886675 Replicon chromosome
Accession NZ_OW969659
Organism Klebsiella oxytoca isolate 36

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag LQ206_RS04275 Protein ID WP_004105559.1
Coordinates 886265..886675 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag LQ206_RS04270 Protein ID WP_004105561.1
Coordinates 886018..886284 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ206_RS04255 (AI2918V1_0831) 881271..881696 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
LQ206_RS04260 (AI2918V1_0832) 881817..884615 - 2799 WP_016809675.1 transcriptional regulator DagR -
LQ206_RS04265 (AI2918V1_0833) 884797..885774 - 978 WP_016809676.1 tRNA-modifying protein YgfZ -
LQ206_RS04270 (AI2918V1_0835) 886018..886284 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
LQ206_RS04275 (AI2918V1_0836) 886265..886675 + 411 WP_004105559.1 protein YgfX Toxin
LQ206_RS04280 (AI2918V1_0837) 886684..887205 - 522 WP_004105557.1 flavodoxin FldB -
LQ206_RS04285 (AI2918V1_0838) 887327..888223 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
LQ206_RS04290 (AI2918V1_0839) 888246..888959 + 714 WP_016809677.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ206_RS04295 (AI2918V1_0840) 888965..890698 + 1734 WP_016809678.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T296149 WP_004105559.1 NZ_OW969659:886265-886675 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT296149 WP_004105561.1 NZ_OW969659:886018-886284 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References