296148

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 658400..658992 Replicon chromosome
Accession NZ_OW969659
Organism Klebsiella oxytoca isolate 36

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag LQ206_RS03190 Protein ID WP_016808034.1
Coordinates 658618..658992 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2J4YM08
Locus tag LQ206_RS03185 Protein ID WP_004105957.1
Coordinates 658400..658621 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ206_RS03165 (AI2918V1_0617) 653961..654515 + 555 WP_004105965.1 YgjV family protein -
LQ206_RS03170 (AI2918V1_0618) 654530..655777 - 1248 WP_004105963.1 serine/threonine transporter SstT -
LQ206_RS03175 (AI2918V1_0619) 656032..657000 - 969 WP_004115718.1 TerC family protein -
LQ206_RS03180 (AI2918V1_0620) 657251..658240 - 990 WP_016808035.1 Gfo/Idh/MocA family oxidoreductase -
LQ206_RS03185 (AI2918V1_0621) 658400..658621 + 222 WP_004105957.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LQ206_RS03190 (AI2918V1_0622) 658618..658992 + 375 WP_016808034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LQ206_RS03195 (AI2918V1_0623) 658972..659475 - 504 WP_004105953.1 M48 family metallopeptidase -
LQ206_RS03200 (AI2918V1_0624) 659554..661197 - 1644 WP_016808033.1 glycoside hydrolase family 43 protein -
LQ206_RS03205 (AI2918V1_0625) 661326..662192 - 867 WP_004105950.1 AraC family transcriptional regulator -
LQ206_RS03210 (AI2918V1_0626) 662300..663643 + 1344 WP_016808032.1 glycoside-pentoside-hexuronide (GPH):cation symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13835.89 Da        Isoelectric Point: 6.0752

>T296148 WP_016808034.1 NZ_OW969659:658618-658992 [Klebsiella oxytoca]
MKWVSASEVIAFHDRILQHLPGVKGMSDPGRAEAIIYRVQNRFHCEGVNDIFELAATYWVAIARGHIFNDGNKRTAFFIT
MTFLARNGYLIADEDTRLEELTVLAATGEATVVVLADALRQLAL

Download         Length: 375 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8185.19 Da        Isoelectric Point: 5.7996

>AT296148 WP_004105957.1 NZ_OW969659:658400-658621 [Klebsiella oxytoca]
MRSYSTSEARQNIAAVMDAAASGEPIEITRRDGTSNVLISKAEYETFMNAKLDAEFDFIMQRHGRTVKALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4YM08

References