Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3804284..3804903 Replicon chromosome
Accession NZ_OW969633
Organism Klebsiella aerogenes isolate 57

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag LQ131_RS18105 Protein ID WP_015367918.1
Coordinates 3804685..3804903 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag LQ131_RS18100 Protein ID WP_015367917.1
Coordinates 3804284..3804658 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ131_RS18090 (3799443) 3799443..3800642 + 1200 WP_047038885.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ131_RS18095 (3800665) 3800665..3803811 + 3147 WP_015367916.1 multidrug efflux RND transporter permease subunit AcrB -
LQ131_RS18100 (3804284) 3804284..3804658 + 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
LQ131_RS18105 (3804685) 3804685..3804903 + 219 WP_015367918.1 HHA domain-containing protein Toxin
LQ131_RS18110 (3805035) 3805035..3805598 + 564 WP_020079452.1 maltose O-acetyltransferase -
LQ131_RS18115 (3805724) 3805724..3806188 + 465 WP_230132976.1 YlaC family protein -
LQ131_RS18120 (3806163) 3806163..3807617 - 1455 WP_045361851.1 PLP-dependent aminotransferase family protein -
LQ131_RS18125 (3807720) 3807720..3808430 + 711 WP_015704607.1 GNAT family protein -
LQ131_RS18130 (3808427) 3808427..3808567 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LQ131_RS18135 (3808570) 3808570..3808830 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T296147 WP_015367918.1 NZ_OW969633:3804685-3804903 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT296147 WP_015367917.1 NZ_OW969633:3804284-3804658 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References