Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2536868..2537607 Replicon chromosome
Accession NZ_OW969633
Organism Klebsiella aerogenes isolate 57

Toxin (Protein)


Gene name tacT Uniprot ID A0A0H3G0L6
Locus tag LQ131_RS12050 Protein ID WP_015705365.1
Coordinates 2537122..2537607 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag LQ131_RS12045 Protein ID WP_015705366.1
Coordinates 2536868..2537134 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ131_RS12020 (2532203) 2532203..2532790 + 588 WP_032705775.1 hypothetical protein -
LQ131_RS12025 (2532787) 2532787..2534106 + 1320 WP_045360842.1 ATP-binding protein -
LQ131_RS12030 (2534106) 2534106..2534723 + 618 WP_045360840.1 response regulator -
LQ131_RS12035 (2534819) 2534819..2535316 + 498 WP_230132898.1 heme-binding protein -
LQ131_RS12040 (2535360) 2535360..2536595 - 1236 WP_230132899.1 MFS transporter -
LQ131_RS12045 (2536868) 2536868..2537134 + 267 WP_015705366.1 DUF1778 domain-containing protein Antitoxin
LQ131_RS12050 (2537122) 2537122..2537607 + 486 WP_015705365.1 GNAT family N-acetyltransferase Toxin
LQ131_RS12055 (2537679) 2537679..2539295 + 1617 WP_157195350.1 FAD-NAD(P)-binding protein -
LQ131_RS12060 (2539414) 2539414..2540514 + 1101 WP_015705363.1 NADH:flavin oxidoreductase/NADH oxidase -
LQ131_RS12065 (2540571) 2540571..2540729 - 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
LQ131_RS12070 (2540990) 2540990..2542060 + 1071 WP_046883609.1 mannonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17603.25 Da        Isoelectric Point: 8.8590

>T296146 WP_015705365.1 NZ_OW969633:2537122-2537607 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHTEATGGLRRNM
PDPIPVIILARLAIDCAYHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT296146 WP_015705366.1 NZ_OW969633:2536868-2537134 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3G0L6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FSM9

References