Detailed information of TA system TA029614

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4364683..4365352
• Replicon: chromosome
• Accession: NC_021659
• Organism: Serratia plymuthica S13

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: S4YKD8
• Locus tag: M621_RS45415
• Protein ID: WP_006327725.1
• Coordinates: 4364683..4365105 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S4YS10
• Locus tag: M621_RS45420
• Protein ID: WP_004952428.1
• Coordinates: 4365086..4365352 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M621_RS45395	4360568..4361086	+	519	WP_004952413.1	flavodoxin FldB	-
M621_RS45400	4361124..4362488	-	1365	WP_004952415.1	cell envelope integrity protein CreD	-
M621_RS45405	4362573..4363991	-	1419	WP_020439698.1	two-component system sensor histidine kinase CreC	-
M621_RS45410	4363988..4364683	-	696	WP_004952420.1	two-component system response regulator CreB	-
M621_RS45415	4364683..4365105	-	423	WP_006327725.1	protein YgfX	Toxin
M621_RS45420	4365086..4365352	-	267	WP_004952428.1	FAD assembly factor SdhE	Antitoxin
M621_RS45425	4365677..4366663	+	987	WP_006327726.1	tRNA-modifying protein YgfZ	-
M621_RS45430	4366717..4367214	-	498	WP_020439699.1	DUF2165 domain-containing protein	-
M621_RS45435	4367378..4368055	-	678	WP_004952439.1	hemolysin III family protein	-
M621_RS45440	4368246..4368854	+	609	WP_004952444.1	HD domain-containing protein	-
M621_RS45445	4368902..4370227	-	1326	WP_020439700.1	MHS family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16461.41 Da
• Isoelectric Point: 11.0260

>T29614 WP_006327725.1 NC_021659:c4365105-4364683 [Serratia plymuthica S13]
VAQWRCNVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLANKRLSWHGQ
EWLLAKQPWMPRYGILLTLQPTQGKKRRRLWLASDSMGKAEWRHLRQLLLHPSADDDEEP

Nucleotide

• Length: 423 bp

>T29614 NC_021659:c4365105-4364683 [Serratia plymuthica S13]
GTGGCCCAGTGGCGATGTAATGTCCGCATTTCCTGGCGCACCCAGCTACTCTCGCTGCTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTACGGCCCGATCTGGCTGGTGTTGTTGACGCTGGTGGTATTTGAATGCA
TCCGCAGCCAAAAGCGCATTGCGTCGCGGCAGGGCGAACTGCGTCTGCTGGCGAATAAGCGTTTAAGTTGGCACGGACAG
GAATGGTTGCTGGCAAAGCAACCCTGGATGCCGCGTTACGGCATTTTGCTGACGCTGCAGCCGACGCAGGGCAAAAAACG
CCGCCGGCTATGGCTGGCCTCCGACAGCATGGGCAAAGCCGAATGGCGGCATCTGCGCCAGTTGTTGCTGCACCCGTCGG
CCGATGATGACGAGGAACCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10446.90 Da
• Isoelectric Point: 5.0843

>AT29614 WP_004952428.1 NC_021659:c4365352-4365086 [Serratia plymuthica S13]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDQLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT29614 NC_021659:c4365352-4365086 [Serratia plymuthica S13]
ATGGATATTAATAATAAAGCACGTATTCACTGGGCCTGCCGCCGTGGCATGCGTGAGCTGGATATCTCAATCATGCCGTT
CTTCGAGCATGAGTACGACCAGTTGAATGACACAGACAAAGCGTTGTTTATCCGCCTGCTTGAGAGCGACGATCCCGATC
TGTTCAACTGGTTGATGAATCATGGCGCTCCGCAAGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTAA

Structures

Toxin

• AlphaFold DB: S4YKD8

Antitoxin

• AlphaFold DB: S4YS10