Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 40907..41643 Replicon plasmid P1
Accession NZ_OW968432
Organism Klebsiella quasipneumoniae isolate 0

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag LQ152_RS24970 Protein ID WP_032429294.1
Coordinates 41161..41643 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag LQ152_RS24965 Protein ID WP_003026799.1
Coordinates 40907..41173 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ152_RS24930 (AI3010V1_4755) 36751..37113 - 363 WP_004206665.1 arsenite efflux transporter metallochaperone ArsD -
LQ152_RS24935 (AI3010V1_4756) 37165..37515 - 351 WP_004206664.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
LQ152_RS24940 (AI3010V1_4757) 37873..38121 + 249 WP_004193994.1 hypothetical protein -
LQ152_RS24945 (AI3010V1_4758) 38118..39329 + 1212 WP_032415728.1 hypothetical protein -
LQ152_RS24950 (AI3010V1_4759) 39463..39954 + 492 WP_004206662.1 hypothetical protein -
LQ152_RS24955 40015..40218 + 204 WP_004206661.1 HHA domain-containing protein -
LQ152_RS24960 (AI3010V1_4760) 40232..40462 + 231 WP_004206660.1 hypothetical protein -
LQ152_RS24965 (AI3010V1_4761) 40907..41173 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
LQ152_RS24970 41161..41643 + 483 WP_032429294.1 GNAT family N-acetyltransferase Toxin
LQ152_RS24975 (AI3010V1_4762) 42060..43157 - 1098 WP_023292115.1 LacI family DNA-binding transcriptional regulator -
LQ152_RS24980 (AI3010V1_4763) 43388..44425 + 1038 WP_023292116.1 SIS domain-containing protein -
LQ152_RS24985 (AI3010V1_4764) 44431..45261 + 831 WP_023292117.1 PfkB family carbohydrate kinase -
LQ152_RS24990 (AI3010V1_4765) 45327..46082 + 756 WP_023292118.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..131788 131788


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17368.00 Da        Isoelectric Point: 9.5822

>T296138 WP_032429294.1 NZ_OW968432:41161-41643 [Klebsiella quasipneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAAFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT296138 WP_003026799.1 NZ_OW968432:40907-41173 [Klebsiella quasipneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References