Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4575312..4575828 Replicon chromosome
Accession NZ_OW968431
Organism Klebsiella quasipneumoniae isolate 0

Toxin (Protein)


Gene name relE Uniprot ID A0A2A5MHL2
Locus tag LQ152_RS22180 Protein ID WP_050533673.1
Coordinates 4575312..4575596 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LQ152_RS22185 Protein ID WP_002886901.1
Coordinates 4575586..4575828 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ152_RS22165 (4570420) 4570420..4572075 + 1656 WP_048322789.1 alpha,alpha-phosphotrehalase -
LQ152_RS22170 (4572461) 4572461..4574599 + 2139 WP_004206513.1 anaerobic ribonucleoside-triphosphate reductase -
LQ152_RS22175 (4574844) 4574844..4575308 + 465 WP_050533674.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LQ152_RS22180 (4575312) 4575312..4575596 - 285 WP_050533673.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ152_RS22185 (4575586) 4575586..4575828 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LQ152_RS22190 (4575906) 4575906..4577816 - 1911 WP_004206509.1 PRD domain-containing protein -
LQ152_RS22195 (4577839) 4577839..4578990 - 1152 WP_230128777.1 lactonase family protein -
LQ152_RS22200 (4579057) 4579057..4579797 - 741 WP_004206507.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11093.90 Da        Isoelectric Point: 10.3341

>T296137 WP_050533673.1 NZ_OW968431:c4575596-4575312 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCDKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT296137 WP_002886901.1 NZ_OW968431:c4575828-4575586 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MHL2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References