Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2564477..2566065 Replicon chromosome
Accession NZ_OW968431
Organism Klebsiella quasipneumoniae isolate 0

Toxin (Protein)


Gene name hipA Uniprot ID A0A5Q9LEV0
Locus tag LQ152_RS12520 Protein ID WP_043519554.1
Coordinates 2564477..2565799 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2A5MFC9
Locus tag LQ152_RS12525 Protein ID WP_004205921.1
Coordinates 2565799..2566065 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ152_RS12480 (2559561) 2559561..2559779 + 219 WP_002904808.1 ParD-like family protein -
LQ152_RS12485 (2559760) 2559760..2560542 + 783 WP_049093365.1 type I methionyl aminopeptidase -
LQ152_RS12490 (2560810) 2560810..2561790 + 981 WP_284446078.1 serine hydrolase domain-containing protein -
LQ152_RS25835 (2561706) 2561706..2561924 + 219 WP_284446079.1 serine hydrolase -
LQ152_RS12500 (2561911) 2561911..2562255 + 345 WP_004205915.1 hypothetical protein -
LQ152_RS12505 (2562284) 2562284..2562817 + 534 WP_230128405.1 DUF2975 domain-containing protein -
LQ152_RS12510 (2562820) 2562820..2563026 + 207 WP_004205917.1 helix-turn-helix transcriptional regulator -
LQ152_RS12515 (2563168) 2563168..2564460 + 1293 WP_069602710.1 glycoside hydrolase family 10 protein -
LQ152_RS12520 (2564477) 2564477..2565799 - 1323 WP_043519554.1 type II toxin-antitoxin system HipA family toxin Toxin
LQ152_RS12525 (2565799) 2565799..2566065 - 267 WP_004205921.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LQ152_RS12530 (2566348) 2566348..2566674 - 327 WP_017900379.1 hydroxyisourate hydrolase -
LQ152_RS12535 (2566671) 2566671..2567171 - 501 WP_017900378.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LQ152_RS12540 (2567149) 2567149..2568528 - 1380 WP_017900377.1 nucleobase:cation symporter-2 family protein -
LQ152_RS12545 (2568874) 2568874..2570028 + 1155 WP_032456029.1 FAD-dependent urate hydroxylase HpxO -
LQ152_RS12550 (2570009) 2570009..2570932 - 924 WP_004205929.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48998.30 Da        Isoelectric Point: 8.2655

>T296135 WP_043519554.1 NZ_OW968431:c2565799-2564477 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLLAG

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9940.38 Da        Isoelectric Point: 7.1997

>AT296135 WP_004205921.1 NZ_OW968431:c2566065-2565799 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LEV0

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MFC9

References