Detailed information of TA system TA029613

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3152967..3153592
• Replicon: chromosome
• Accession: NC_021659
• Organism: Serratia plymuthica S13

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S4YKF9
• Locus tag: M621_RS50905
• Protein ID: WP_020439240.1
• Coordinates: 3152967..3153149 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: S4YHW4
• Locus tag: M621_RS39870
• Protein ID: WP_006326094.1
• Coordinates: 3153179..3153592 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M621_RS39860	3148481..3148726	-	246	WP_020439238.1	hypothetical protein	-
M621_RS39865	3148829..3152800	+	3972	WP_020439239.1	trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	-
M621_RS50905	3152967..3153149	+	183	WP_020439240.1	type II toxin-antitoxin system HicA family toxin	Toxin
M621_RS39870	3153179..3153592	+	414	WP_006326094.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
M621_RS39875	3153625..3154377	-	753	WP_004945934.1	L-cystine ABC transporter ATP-binding protein YecC	-
M621_RS39880	3154381..3155043	-	663	WP_004945937.1	cystine ABC transporter permease	-
M621_RS39885	3155043..3155843	-	801	WP_006326095.1	cystine ABC transporter substrate-binding protein	-
M621_RS39890	3155957..3156949	-	993	WP_020439241.1	D-cysteine desulfhydrase	-
M621_RS39895	3157075..3157584	-	510	WP_004945946.1	flagella biosynthesis regulatory protein FliZ	-
M621_RS39900	3157641..3158363	-	723	WP_004945948.1	RNA polymerase sigma factor FliA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (7-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6891.13 Da
• Isoelectric Point: 11.0382

>T29613 WP_020439240.1 NC_021659:3152967-3153149 [Serratia plymuthica S13]
VKSAEPIRLLEREGWVLERIKGSHHQFKHPSSRLVITVPHPRKDLKPGTLRQIMKDAGLC

Nucleotide

• Length: 183 bp

>T29613 NC_021659:3152967-3153149 [Serratia plymuthica S13]
GTGAAAAGTGCAGAACCGATCAGGCTGTTAGAACGGGAAGGTTGGGTTTTAGAGCGGATAAAGGGAAGCCACCATCAGTT
CAAACACCCGAGTTCCCGTCTGGTGATCACCGTTCCACACCCGCGTAAAGATCTGAAGCCGGGAACGCTGCGCCAAATCA
TGAAAGATGCCGGGCTGTGCTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15156.85 Da
• Isoelectric Point: 4.5728

>AT29613 WP_006326094.1 NC_021659:3153179-3153592 [Serratia plymuthica S13]
MFYPAYVHSDYDGSASGFFPDVPGCYFAGDTLDKAFEDAKGALDAHFELLSEDNQAIPRPQAVSFHLAQENDALNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSVVQQHPGYGSRSAFLAAAARNELLKVD

Nucleotide

• Length: 414 bp

>AT29613 NC_021659:3153179-3153592 [Serratia plymuthica S13]
ATGTTCTACCCTGCTTATGTACATTCAGACTACGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGCTGTTATTT
TGCCGGCGACACCCTAGATAAAGCCTTTGAAGATGCCAAAGGCGCGCTGGACGCGCATTTCGAACTTCTGAGCGAAGACA
ACCAGGCCATCCCGCGCCCACAGGCCGTTTCCTTCCATCTGGCACAGGAAAACGACGCCCTGAACGGCGGGCAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCGATGGGCGGGCGGAACGGATAAATATCACCCTGCCGCACCGCTTGCTGAACCG
CATCGATTCAGTGGTGCAGCAGCATCCTGGCTATGGGAGCCGCAGCGCCTTTTTGGCCGCAGCCGCCCGTAATGAATTAT
TGAAAGTCGATTAG

Structures

Toxin

• AlphaFold DB: S4YKF9

Antitoxin

• AlphaFold DB: S4YHW4