Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4609717..4610333 Replicon chromosome
Accession NZ_OW968417
Organism Enterobacter cloacae isolate 764

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LQ125_RS22190 Protein ID WP_080339264.1
Coordinates 4609717..4610088 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag LQ125_RS22195 Protein ID WP_023298920.1
Coordinates 4610091..4610333 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ125_RS22175 (AI3013V2_4296) 4607217..4608119 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
LQ125_RS22180 (AI3013V2_4297) 4608116..4608751 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
LQ125_RS22185 (AI3013V2_4298) 4608748..4609677 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
LQ125_RS22190 (AI3013V2_4299) 4609717..4610088 - 372 WP_080339264.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ125_RS22195 (AI3013V2_4300) 4610091..4610333 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
LQ125_RS22200 (AI3013V2_4301) 4610533..4611453 + 921 WP_163346823.1 alpha/beta hydrolase -
LQ125_RS22205 (AI3013V2_4302) 4611462..4612403 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
LQ125_RS22210 (AI3013V2_4303) 4612448..4612885 - 438 WP_063150747.1 D-aminoacyl-tRNA deacylase -
LQ125_RS22215 (AI3013V2_4304) 4612882..4613763 - 882 WP_023298923.1 virulence factor BrkB family protein -
LQ125_RS22220 (AI3013V2_4305) 4613757..4614356 - 600 WP_003861947.1 glucose-1-phosphatase -
LQ125_RS22225 (AI3013V2_4306) 4614475..4615275 - 801 WP_023298924.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13596.66 Da        Isoelectric Point: 6.4866

>T296123 WP_080339264.1 NZ_OW968417:c4610088-4609717 [Enterobacter cloacae]
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT296123 WP_023298920.1 NZ_OW968417:c4610333-4610091 [Enterobacter cloacae]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References