Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3743962..3744619 Replicon chromosome
Accession NZ_OW968417
Organism Enterobacter cloacae isolate 764

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag LQ125_RS18090 Protein ID WP_022649305.1
Coordinates 3743962..3744372 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LQ125_RS18095 Protein ID WP_003863437.1
Coordinates 3744353..3744619 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ125_RS18070 (AI3013V2_3496) 3739960..3741693 - 1734 WP_163347529.1 single-stranded-DNA-specific exonuclease RecJ -
LQ125_RS18075 (AI3013V2_3497) 3741699..3742412 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ125_RS18080 (AI3013V2_3498) 3742441..3743337 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
LQ125_RS18085 (AI3013V2_3499) 3743439..3743960 + 522 WP_015571793.1 flavodoxin FldB -
LQ125_RS18090 (AI3013V2_3500) 3743962..3744372 - 411 WP_022649305.1 protein YgfX Toxin
LQ125_RS18095 (AI3013V2_3501) 3744353..3744619 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LQ125_RS18100 (AI3013V2_3502) 3744914..3745894 + 981 WP_063854323.1 tRNA-modifying protein YgfZ -
LQ125_RS18105 (AI3013V2_3503) 3746415..3747074 - 660 WP_022649307.1 hemolysin III family protein -
LQ125_RS18110 (AI3013V2_3504) 3747341..3748072 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T296122 WP_022649305.1 NZ_OW968417:c3744372-3743962 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT296122 WP_003863437.1 NZ_OW968417:c3744619-3744353 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References