Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2281257..2281996 Replicon chromosome
Accession NZ_OW968417
Organism Enterobacter cloacae isolate 764

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag LQ125_RS11080 Protein ID WP_163347044.1
Coordinates 2281257..2281742 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag LQ125_RS11085 Protein ID WP_003857131.1
Coordinates 2281730..2281996 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ125_RS11045 (AI3013V2_2143) 2276282..2277040 - 759 WP_032624253.1 trans-aconitate 2-methyltransferase -
LQ125_RS11050 (AI3013V2_2144) 2277125..2277709 - 585 WP_058676643.1 NUDIX domain-containing protein -
LQ125_RS11055 (AI3013V2_2145) 2277796..2278554 + 759 WP_163347047.1 DeoR/GlpR family DNA-binding transcription regulator -
LQ125_RS11060 (AI3013V2_2146) 2278659..2279951 + 1293 WP_163347045.1 glycosyl hydrolase family 28 protein -
LQ125_RS11065 (AI3013V2_2147) 2280278..2280523 - 246 WP_163347006.1 hypothetical protein -
LQ125_RS11070 (AI3013V2_2148) 2280657..2280830 + 174 WP_234035923.1 hypothetical protein -
LQ125_RS11075 (AI3013V2_2149) 2280827..2281231 + 405 WP_234035924.1 hypothetical protein -
LQ125_RS11080 (AI3013V2_2150) 2281257..2281742 - 486 WP_163347044.1 GNAT family N-acetyltransferase Toxin
LQ125_RS11085 (AI3013V2_2151) 2281730..2281996 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
LQ125_RS11090 (AI3013V2_2152) 2282060..2282989 - 930 WP_163347042.1 LysR family transcriptional regulator -
LQ125_RS11095 (AI3013V2_2153) 2283119..2284507 + 1389 WP_163347040.1 MFS transporter -
LQ125_RS11100 (AI3013V2_2154) 2284486..2285043 - 558 WP_023300131.1 OmpH family outer membrane protein -
LQ125_RS11105 (AI3013V2_2155) 2285164..2286300 - 1137 WP_023300132.1 type 1 fimbrial protein -
LQ125_RS11110 (AI3013V2_2156) 2286324..2286902 - 579 WP_022648146.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2266554..2281996 15442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17500.15 Da        Isoelectric Point: 9.6275

>T296117 WP_163347044.1 NZ_OW968417:c2281742-2281257 [Enterobacter cloacae]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNI
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT296117 WP_003857131.1 NZ_OW968417:c2281996-2281730 [Enterobacter cloacae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References