Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1076283..1076904 Replicon chromosome
Accession NZ_OW968417
Organism Enterobacter cloacae isolate 764

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag LQ125_RS05170 Protein ID WP_015571250.1
Coordinates 1076283..1076501 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag LQ125_RS05175 Protein ID WP_006809850.1
Coordinates 1076530..1076904 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ125_RS05140 (AI3013V2_0998) 1072296..1072556 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
LQ125_RS05145 (AI3013V2_0999) 1072559..1072699 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LQ125_RS05150 (AI3013V2_1000) 1072696..1073406 - 711 WP_163346922.1 GNAT family protein -
LQ125_RS05155 (AI3013V2_1001) 1073509..1074969 + 1461 WP_163346924.1 PLP-dependent aminotransferase family protein -
LQ125_RS05160 (AI3013V2_1002) 1074941..1075408 - 468 WP_022647269.1 YlaC family protein -
LQ125_RS05165 (AI3013V2_1003) 1075525..1076076 - 552 WP_022647270.1 maltose O-acetyltransferase -
LQ125_RS05170 (AI3013V2_1004) 1076283..1076501 - 219 WP_015571250.1 HHA domain-containing protein Toxin
LQ125_RS05175 (AI3013V2_1005) 1076530..1076904 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
LQ125_RS05180 (AI3013V2_1006) 1077414..1080560 - 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit AcrB -
LQ125_RS05185 (AI3013V2_1007) 1080583..1081776 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T296116 WP_015571250.1 NZ_OW968417:c1076501-1076283 [Enterobacter cloacae]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT296116 WP_006809850.1 NZ_OW968417:c1076904-1076530 [Enterobacter cloacae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References