Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 3904..4475 Replicon plasmid P1
Accession NZ_OW968329
Organism Enterobacter cloacae isolate 1382

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LQ108_RS23235 Protein ID WP_089564743.1
Coordinates 4188..4475 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LQ108_RS23230 Protein ID WP_089564742.1
Coordinates 3904..4188 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ108_RS23210 (1) 1..858 + 858 WP_016240488.1 incFII family plasmid replication initiator RepA -
LQ108_RS23215 (1866) 1866..2129 + 264 WP_089564739.1 plasmid stabilization protein -
LQ108_RS23220 (2119) 2119..2418 + 300 WP_089564740.1 type II toxin-antitoxin system RelE/ParE family toxin -
LQ108_RS23225 (2559) 2559..3536 + 978 WP_089564741.1 DUF4238 domain-containing protein -
LQ108_RS23230 (3904) 3904..4188 + 285 WP_089564742.1 ribbon-helix-helix domain-containing protein Antitoxin
LQ108_RS23235 (4188) 4188..4475 + 288 WP_089564743.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ108_RS23240 (4745) 4745..6487 - 1743 WP_115763508.1 ATP-binding cassette domain-containing protein -
LQ108_RS23245 (6490) 6490..8031 - 1542 WP_112868038.1 lasso peptide isopeptide bond-forming cyclase -
LQ108_RS23250 (8034) 8034..8660 - 627 WP_001513515.1 lasso peptide biosynthesis B2 protein -
LQ108_RS23255 (9000) 9000..9176 + 177 WP_001513516.1 lasso peptide microcin J25 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..72965 72965


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-79)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11038.91 Da        Isoelectric Point: 10.2768

>T296102 WP_089564743.1 NZ_OW968329:4188-4475 [Enterobacter cloacae]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQVPIILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIW
GPHGIRKINHVKTIF

Download         Length: 288 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10545.97 Da        Isoelectric Point: 5.6558

>AT296102 WP_089564742.1 NZ_OW968329:3904-4188 [Enterobacter cloacae]
MQMKNNTAQTTKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLNTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References