Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4814416..4815032 Replicon chromosome
Accession NZ_OW968328
Organism Enterobacter cloacae isolate 1382

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LQ108_RS22865 Protein ID WP_230137126.1
Coordinates 4814416..4814787 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LQ108_RS22870 Protein ID WP_046889539.1
Coordinates 4814790..4815032 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ108_RS22850 (AI2999V1_4436) 4811916..4812818 + 903 WP_014833793.1 formate dehydrogenase subunit beta -
LQ108_RS22855 (AI2999V1_4437) 4812815..4813450 + 636 WP_023622447.1 formate dehydrogenase cytochrome b556 subunit -
LQ108_RS22860 (AI2999V1_4438) 4813447..4814376 + 930 WP_029882351.1 formate dehydrogenase accessory protein FdhE -
LQ108_RS22865 (AI2999V1_4439) 4814416..4814787 - 372 WP_230137126.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ108_RS22870 (AI2999V1_4440) 4814790..4815032 - 243 WP_046889539.1 ribbon-helix-helix domain-containing protein Antitoxin
LQ108_RS22875 (AI2999V1_4441) 4815232..4816149 + 918 WP_230137128.1 alpha/beta hydrolase -
LQ108_RS22880 (AI2999V1_4442) 4816162..4817103 - 942 WP_013099362.1 fatty acid biosynthesis protein FabY -
LQ108_RS22885 (AI2999V1_4443) 4817148..4817585 - 438 WP_013099363.1 D-aminoacyl-tRNA deacylase -
LQ108_RS22890 (AI2999V1_4444) 4817582..4818463 - 882 WP_013099364.1 virulence factor BrkB family protein -
LQ108_RS22895 (AI2999V1_4445) 4818457..4819056 - 600 WP_139937197.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13627.72 Da        Isoelectric Point: 6.6407

>T296101 WP_230137126.1 NZ_OW968328:c4814787-4814416 [Enterobacter cloacae]
MNNMAVFDTNILIDLFNNRVEAADAIDHAASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEVIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVVTPYQL

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9413.69 Da        Isoelectric Point: 4.3224

>AT296101 WP_046889539.1 NZ_OW968328:c4815032-4814790 [Enterobacter cloacae]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRDALGLWGDKKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References