Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4021589..4022370 Replicon chromosome
Accession NZ_OW968328
Organism Enterobacter cloacae isolate 1382

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag LQ108_RS19115 Protein ID WP_230136712.1
Coordinates 4021589..4022080 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A5E1AUV7
Locus tag LQ108_RS19120 Protein ID WP_029882966.1
Coordinates 4022077..4022370 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ108_RS19095 (AI2999V1_3712) 4017329..4018021 + 693 WP_013098687.1 response regulator -
LQ108_RS19100 (AI2999V1_3713) 4018120..4020255 - 2136 WP_023621449.1 ornithine decarboxylase -
LQ108_RS19105 (AI2999V1_3714) 4020438..4021151 + 714 WP_013098689.1 DUF554 domain-containing protein -
LQ108_RS19115 (AI2999V1_3715) 4021589..4022080 - 492 WP_230136712.1 GNAT family N-acetyltransferase Toxin
LQ108_RS19120 (AI2999V1_3716) 4022077..4022370 - 294 WP_029882966.1 DUF1778 domain-containing protein Antitoxin
LQ108_RS19125 (AI2999V1_3717) 4022619..4024406 - 1788 WP_219247822.1 hybrid sensor histidine kinase/response regulator -
LQ108_RS19130 (AI2999V1_3718) 4024403..4025035 - 633 WP_013098693.1 response regulator transcription factor -
LQ108_RS19135 (AI2999V1_3719) 4025211..4025525 + 315 WP_013098694.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17628.58 Da        Isoelectric Point: 8.1484

>T296100 WP_230136712.1 NZ_OW968328:c4022080-4021589 [Enterobacter cloacae]
MISAPKPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVSGASRTFVCCGNDSNVLAYYSLASSAVMTNTAPGRFRRNMPDP
IPVVVLGRLAVDQSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMILMVTLGDLM
ASI

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11003.66 Da        Isoelectric Point: 9.9156

>AT296100 WP_029882966.1 NZ_OW968328:c4022370-4022077 [Enterobacter cloacae]
MPAANTMAMKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQAPAPN
ATLRKTMQTPAPWEREK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AUV7

References