Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3287624..3289407 Replicon chromosome
Accession NZ_OW968328
Organism Enterobacter cloacae isolate 1382

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LQ108_RS15650 Protein ID WP_023619763.1
Coordinates 3287624..3288973 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LQ108_RS15655 Protein ID WP_029883072.1
Coordinates 3288970..3289407 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ108_RS15620 (AI2999V1_3047) 3282779..3283576 - 798 WP_230136392.1 helix-turn-helix transcriptional regulator -
LQ108_RS15625 (AI2999V1_3048) 3283636..3284352 + 717 WP_094916089.1 type 1 glutamine amidotransferase -
LQ108_RS15630 (AI2999V1_3049) 3284544..3284942 + 399 WP_023619766.1 CidA/LrgA family protein -
LQ108_RS15635 (AI2999V1_3050) 3284939..3285634 + 696 WP_230136394.1 CidB/LrgB family autolysis modulator -
LQ108_RS15640 (AI2999V1_3051) 3285764..3286648 + 885 WP_023619765.1 cytidine deaminase -
LQ108_RS15645 (AI2999V1_3052) 3286776..3287489 + 714 WP_023619764.1 outer membrane permeability protein SanA -
LQ108_RS15650 (AI2999V1_3053) 3287624..3288973 + 1350 WP_023619763.1 HipA domain-containing protein Toxin
LQ108_RS15655 3288970..3289407 + 438 WP_029883072.1 helix-turn-helix transcriptional regulator Antitoxin
LQ108_RS15660 (AI2999V1_3054) 3289459..3290469 - 1011 WP_013097952.1 galactose/methyl galactoside ABC transporter permease MglC -
LQ108_RS15665 (AI2999V1_3055) 3290485..3292005 - 1521 WP_029883073.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
LQ108_RS15670 (AI2999V1_3056) 3292086..3293084 - 999 WP_014832691.1 galactose/glucose ABC transporter substrate-binding protein MglB -
LQ108_RS15675 (AI2999V1_3057) 3293380..3294402 - 1023 WP_029883074.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51149.69 Da        Isoelectric Point: 4.5348

>T296098 WP_023619763.1 NZ_OW968328:3287624-3288973 [Enterobacter cloacae]
METLTVQAYLNETWTDIALIKYPGSENNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDQGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNEFARTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVDTMR
LEEGSHYPSLWLPRFDIVRNEQDQLIRLGMESVYSLLQKAPGTLLDHEATLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENHIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNAIAQALAEWIPPTT
LLDALHETAVQLIDLPERLEARGVPDQIMEMPAIGFRYIPNKLSRWGLL

Download         Length: 1350 bp

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16218.68 Da        Isoelectric Point: 10.6347

>AT296098 WP_029883072.1 NZ_OW968328:3288970-3289407 [Enterobacter cloacae]
MKISNKSESELLQTLARVRSVNEKRRHDEDEDPDKSSVVKRQRVSSGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGMKQDEYAKLVSVSRKTLSDVENGRGNYSADIINKIFKPFGLQTGLVPISKSLIASLFT

Download         Length: 438 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References