Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1066524..1067144 Replicon chromosome
Accession NZ_OW968328
Organism Enterobacter cloacae isolate 1382

Toxin (Protein)


Gene name Hha Uniprot ID A0A5E1A1U8
Locus tag LQ108_RS05020 Protein ID WP_013095889.1
Coordinates 1066524..1066742 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag LQ108_RS05025 Protein ID WP_008499288.1
Coordinates 1066770..1067144 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ108_RS04990 (AI2999V1_0970) 1062536..1062796 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
LQ108_RS04995 1062799..1062939 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LQ108_RS05000 (AI2999V1_0971) 1062936..1063646 - 711 WP_230134442.1 GNAT family protein -
LQ108_RS05005 (AI2999V1_0972) 1063748..1065208 + 1461 WP_230134445.1 PLP-dependent aminotransferase family protein -
LQ108_RS05010 (AI2999V1_0973) 1065180..1065647 - 468 WP_013095887.1 YlaC family protein -
LQ108_RS05015 (AI2999V1_0974) 1065763..1066314 - 552 WP_013095888.1 maltose O-acetyltransferase -
LQ108_RS05020 (AI2999V1_0975) 1066524..1066742 - 219 WP_013095889.1 HHA domain-containing protein Toxin
LQ108_RS05025 (AI2999V1_0976) 1066770..1067144 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
LQ108_RS05030 (AI2999V1_0977) 1067657..1070803 - 3147 WP_013095890.1 multidrug efflux RND transporter permease subunit AcrB -
LQ108_RS05035 (AI2999V1_0978) 1070826..1072019 - 1194 WP_023620093.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8625.98 Da        Isoelectric Point: 8.9008

>T296092 WP_013095889.1 NZ_OW968328:c1066742-1066524 [Enterobacter cloacae]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELTVFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT296092 WP_008499288.1 NZ_OW968328:c1067144-1066770 [Enterobacter cloacae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1A1U8

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References