Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 599803..600597 Replicon chromosome
Accession NZ_OW968328
Organism Enterobacter cloacae isolate 1382

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag LQ108_RS02820 Protein ID WP_230134223.1
Coordinates 599803..600324 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A5E1AP76
Locus tag LQ108_RS02825 Protein ID WP_013095428.1
Coordinates 600328..600597 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ108_RS02795 (AI2999V1_0543) 595130..595291 + 162 WP_003863073.1 DUF1127 domain-containing protein -
LQ108_RS02800 (AI2999V1_0544) 595378..596766 - 1389 WP_230134221.1 PLP-dependent aminotransferase family protein -
LQ108_RS02805 (AI2999V1_0545) 596869..597348 + 480 WP_013095424.1 carboxymuconolactone decarboxylase family protein -
LQ108_RS02810 (AI2999V1_0546) 597335..598237 - 903 WP_038981742.1 LysR family transcriptional regulator -
LQ108_RS02815 (AI2999V1_0547) 598338..599753 + 1416 WP_230134222.1 aldehyde dehydrogenase family protein -
LQ108_RS02820 (AI2999V1_0548) 599803..600324 - 522 WP_230134223.1 GNAT family N-acetyltransferase Toxin
LQ108_RS02825 (AI2999V1_0549) 600328..600597 - 270 WP_013095428.1 DUF1778 domain-containing protein Antitoxin
LQ108_RS02830 (AI2999V1_0550) 600812..601135 + 324 WP_023620659.1 antibiotic biosynthesis monooxygenase -
LQ108_RS02835 (AI2999V1_0551) 601128..601526 + 399 WP_029882197.1 hypothetical protein -
LQ108_RS02840 (AI2999V1_0552) 601498..602193 + 696 WP_230134224.1 winged helix-turn-helix domain-containing protein -
LQ108_RS02845 (AI2999V1_0553) 602398..602868 + 471 WP_013095432.1 MarR family transcriptional regulator -
LQ108_RS02850 (AI2999V1_0554) 602865..603932 + 1068 WP_128311826.1 HlyD family secretion protein -
LQ108_RS02855 (AI2999V1_0555) 603922..604998 + 1077 WP_230134225.1 DUF2955 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-150)

Antitoxin

Vibrio phage ICP1, Orf50

(3-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19383.26 Da        Isoelectric Point: 8.9007

>T296091 WP_230134223.1 NZ_OW968328:c600324-599803 [Enterobacter cloacae]
VNNMKIGIFSDDVEYDLSHFDCGEESLNTFLTAHLKRQHRGKFLRGYVLVASGEKPRVLGYYTLSGSCFEKAYLPSKTQQ
KRVPYKNVPSVTLGRLAIDTRFQGQGLGELLVTHALKTVYLASFAVGIHGIFVEALNDSAKNFYLKLGFIALQAENENTL
FLPTKTIERLFAD

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10177.54 Da        Isoelectric Point: 5.8652

>AT296091 WP_013095428.1 NZ_OW968328:c600597-600328 [Enterobacter cloacae]
MSALKKQRIDLRLTEDDKSLIEEAAAMTNQSISQFMVSTASERAAEVIEQHRRLILNEASWNQVMDAISNPPTPNERLKR
AARRLQDLE

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AP76

References