Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 523383..523899 Replicon chromosome
Accession NZ_OW968328
Organism Enterobacter cloacae isolate 1382

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LQ108_RS02475 Protein ID WP_095427819.1
Coordinates 523615..523899 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag LQ108_RS02470 Protein ID WP_008501400.1
Coordinates 523383..523625 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ108_RS02455 (AI2999V1_0478) 519377..520117 + 741 WP_219248979.1 KDGP aldolase family protein -
LQ108_RS02460 (AI2999V1_0479) 520239..521375 + 1137 WP_230134200.1 lactonase family protein -
LQ108_RS02465 (AI2999V1_0480) 521395..523305 + 1911 WP_058651172.1 PRD domain-containing protein -
LQ108_RS02470 (AI2999V1_0481) 523383..523625 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LQ108_RS02475 (AI2999V1_0482) 523615..523899 + 285 WP_095427819.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ108_RS02480 (AI2999V1_0483) 523903..524367 - 465 WP_230134201.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LQ108_RS02485 (AI2999V1_0484) 524490..526628 - 2139 WP_013095357.1 anaerobic ribonucleoside-triphosphate reductase -
LQ108_RS02490 (AI2999V1_0485) 527002..528645 - 1644 WP_230134202.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11001.93 Da        Isoelectric Point: 10.4610

>T296090 WP_095427819.1 NZ_OW968328:523615-523899 [Enterobacter cloacae]
MTYELEFDPRALKEWSKLGETVKKQFRKKLAGVLVNPRIESARLHTLPDCYKIKLRSQGYRLVYQVQDNVVTVVVIAIGK
REKLTVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT296090 WP_008501400.1 NZ_OW968328:523383-523625 [Enterobacter cloacae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References