Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 178603..179207 Replicon chromosome
Accession NZ_OW968328
Organism Enterobacter cloacae isolate 1382

Toxin (Protein)


Gene name hicA Uniprot ID A0A421IJD5
Locus tag LQ108_RS00865 Protein ID WP_071843252.1
Coordinates 178603..178788 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7Z1F6W0
Locus tag LQ108_RS00870 Protein ID WP_013094943.1
Coordinates 178803..179207 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ108_RS00850 (AI2999V1_0170) 175034..176572 + 1539 WP_020686520.1 aldehyde dehydrogenase family protein -
LQ108_RS00855 (AI2999V1_0171) 176569..177534 - 966 WP_150057789.1 LysR family transcriptional regulator -
LQ108_RS00860 (AI2999V1_0172) 177652..178392 + 741 WP_013094942.1 MipA/OmpV family protein -
LQ108_RS00865 178603..178788 + 186 WP_071843252.1 type II toxin-antitoxin system HicA family toxin Toxin
LQ108_RS00870 (AI2999V1_0173) 178803..179207 + 405 WP_013094943.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LQ108_RS00875 (AI2999V1_0174) 179261..181216 - 1956 WP_230134124.1 glycoside hydrolase family 127 protein -
LQ108_RS00880 (AI2999V1_0175) 181227..182627 - 1401 WP_020686524.1 MFS transporter -
LQ108_RS00885 (AI2999V1_0176) 182852..183670 + 819 WP_020686525.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6859.08 Da        Isoelectric Point: 11.7891

>T296089 WP_071843252.1 NZ_OW968328:178603-178788 [Enterobacter cloacae]
VKSADVITVLVRHGWKCVRTKGSHHQFRHPVHAGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14915.74 Da        Isoelectric Point: 4.3036

>AT296089 WP_013094943.1 NZ_OW968328:178803-179207 [Enterobacter cloacae]
MFYPAYIHSDPDGSASGFFPDVPGCFFAGNSLDDAFQDARDALTAHFEALFEMDEELPLPGNVEAHLEATPGDFIGGQWL
LVDINMKQFDGKAERINITLPRRLLVKIDSFVNEHPQFSNRSAFLAEAARRVLP

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A421IJD5

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z1F6W0

References