Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4121193..4121769 Replicon chromosome
Accession NZ_OW968288
Organism Escherichia coli isolate 10

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag LQ134_RS20000 Protein ID WP_001297643.1
Coordinates 4121482..4121769 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag LQ134_RS19995 Protein ID WP_000063156.1
Coordinates 4121193..4121495 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ134_RS19980 (4117789) 4117789..4119939 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
LQ134_RS19985 (4119989) 4119989..4120192 + 204 WP_000467859.1 YbdD/YjiX family protein -
LQ134_RS19990 (4120203) 4120203..4121159 + 957 WP_001297640.1 GTPase -
LQ134_RS19995 (4121193) 4121193..4121495 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
LQ134_RS20000 (4121482) 4121482..4121769 - 288 WP_001297643.1 BrnT family toxin Toxin
LQ134_RS20005 (4121968) 4121968..4122665 - 698 Protein_3933 IS1 family transposase -
LQ134_RS20010 (4122722) 4122722..4122817 + 96 Protein_3934 dienelactone hydrolase family protein -
LQ134_RS20015 (4122963) 4122963..4124195 + 1233 WP_063104094.1 multidrug efflux MFS transporter MdtM -
LQ134_RS20020 (4124236) 4124236..4125516 + 1281 WP_001037380.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T296074 WP_001297643.1 NZ_OW968288:c4121769-4121482 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT296074 WP_000063156.1 NZ_OW968288:c4121495-4121193 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References