Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2490347..2490985 Replicon chromosome
Accession NZ_OW968288
Organism Escherichia coli isolate 10

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag LQ134_RS12060 Protein ID WP_001447010.1
Coordinates 2490809..2490985 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LQ134_RS12055 Protein ID WP_001270286.1
Coordinates 2490347..2490763 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ134_RS12035 (2485499) 2485499..2486440 - 942 WP_001251304.1 ABC transporter permease -
LQ134_RS12040 (2486441) 2486441..2487454 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
LQ134_RS12045 (2487472) 2487472..2488617 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
LQ134_RS12050 (2488862) 2488862..2490268 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
LQ134_RS12055 (2490347) 2490347..2490763 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LQ134_RS12060 (2490809) 2490809..2490985 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LQ134_RS12065 (2491207) 2491207..2491437 + 231 WP_000494244.1 YncJ family protein -
LQ134_RS12070 (2491529) 2491529..2493490 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LQ134_RS12075 (2493563) 2493563..2494099 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
LQ134_RS12080 (2494191) 2494191..2495366 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T296070 WP_001447010.1 NZ_OW968288:c2490985-2490809 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT296070 WP_001270286.1 NZ_OW968288:c2490763-2490347 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References