Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 858407..859061 Replicon chromosome
Accession NZ_OW968288
Organism Escherichia coli isolate 10

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag LQ134_RS04175 Protein ID WP_000244777.1
Coordinates 858654..859061 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LQ134_RS04170 Protein ID WP_000354046.1
Coordinates 858407..858673 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ134_RS04145 (853576) 853576..854319 + 744 WP_000951964.1 SDR family oxidoreductase -
LQ134_RS04150 (854376) 854376..855809 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
LQ134_RS04155 (855854) 855854..856165 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
LQ134_RS04160 (856329) 856329..856988 + 660 WP_000250274.1 hemolysin III family protein -
LQ134_RS04165 (857184) 857184..858164 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
LQ134_RS04170 (858407) 858407..858673 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LQ134_RS04175 (858654) 858654..859061 + 408 WP_000244777.1 protein YgfX Toxin
LQ134_RS04180 (859101) 859101..859622 - 522 WP_001055874.1 flavodoxin FldB -
LQ134_RS04185 (859734) 859734..860630 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LQ134_RS04190 (860655) 860655..861365 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ134_RS04195 (861371) 861371..863104 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T296061 WP_000244777.1 NZ_OW968288:858654-859061 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT296061 WP_000354046.1 NZ_OW968288:858407-858673 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References