296056

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 4632865..4633684 Replicon chromosome
Accession NZ_OW968280
Organism Klebsiella oxytoca isolate 101

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag LQ191_RS21870 Protein ID WP_004110819.1
Coordinates 4633427..4633684 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag LQ191_RS21865 Protein ID WP_126488543.1
Coordinates 4632865..4633416 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ191_RS21845 (AI2946V1_4276) 4628715..4629992 + 1278 WP_024273764.1 hypothetical protein -
LQ191_RS21850 (AI2946V1_4277) 4630010..4631173 + 1164 WP_024273763.1 MFS transporter -
LQ191_RS21855 4631219..4631983 - 765 WP_224227635.1 class I SAM-dependent methyltransferase -
LQ191_RS21860 4632365..4632751 - 387 Protein_4303 class I SAM-dependent methyltransferase -
LQ191_RS21865 (AI2946V1_4279) 4632865..4633416 - 552 WP_126488543.1 N-acetyltransferase Antitoxin
LQ191_RS21870 (AI2946V1_4280) 4633427..4633684 - 258 WP_004110819.1 YjhX family toxin Toxin
LQ191_RS21875 (AI2946V1_4281) 4634266..4635450 + 1185 WP_004099225.1 mannonate dehydratase -
LQ191_RS21880 (AI2946V1_4282) 4635525..4637000 + 1476 WP_126488541.1 fructuronate reductase -
LQ191_RS21885 (AI2946V1_4283) 4637136..4637912 + 777 WP_017146569.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4627423..4628583 1160


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(17-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T296056 WP_004110819.1 NZ_OW968280:c4633684-4633427 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20133.09 Da        Isoelectric Point: 6.7176

>AT296056 WP_126488543.1 NZ_OW968280:c4633416-4632865 [Klebsiella oxytoca]
MTNHNFTFHITSERDADDIREVETRAFGFSKEADLVAALLNDESAHPSLSLLAKHNGKAVGHILFTLATFKGESDSPMMH
ILAPLAVVPEYQGMGVGGLLIQSGIEHLKAMGSLAVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMLQRLSS
RPLGITGQIQCARALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure

References